A decline of LAMP- 2 predicts ursodeoxycholic acid response in primary biliary cirrhosis.
A decline of LAMP- 2 predicts ursodeoxycholic acid response in primary biliary cirrhosis.
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LAMP-2 的下降预示着原发性胆汁性肝硬化中熊去氧胆酸的反应。
DOI：
10.1038/srep09772
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发表时间：
2015-04-20
影响因子：
4.6
通讯作者：
Fan DM
中科院分区：
文献类型：
--
作者：
Wang L;Guo GY;Wang JB;Zhou XM;Yang Q;Han ZY;Li Q;Zhang JW;Cai Y;Ren XL;Zhou X;Chen RR;Shi YQ;Han Y;Fan DM
原发性胆汁性肝硬化（PBC）患者对熊去氧胆酸（UDCA）的生化反应是可变的。我们以前曾报道过溶酶体相关膜蛋白2（LAMP-2）的表达增加与PBC的严重程度相关。本研究旨在确定血清LAMP-2是否可作为UDCA生化反应的预测因子。通过回顾性分析，评估PBC患者接受UDCA治疗1年后血清LAMP-2预测生化应答的有效性。我们发现PBC患者的基础血清LAMP-2水平升高，尤其是III-IV期（p = 0.010）或TBIL > 1 mg/dL（p = 0.014）患者。无应答者的基线血清LAMP-2水平高于应答者，但差异无统计学意义。但UDCA治疗后3个月内血清LAMP-2水平显著下降，且在应答者中更明显。进一步研究表明，治疗3个月后LAMP-2下降35%可作为UDCA反应的指标，根据巴黎标准，其敏感性为62.9%，特异性为75.0%。Barcelona诊断标准的特异性和敏感性分别为63.5%和64.1%。总之，LAMP-2的下降可能有助于预测对UDCA的反应。
Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. We have previously reported that augmented expression of lysosome-associated membrane protein 2 (LAMP-2) was correlated with the severity of PBC. This study aimed to determine whether serum LAMP-2 could serve as a predictor of biochemical response to UDCA. The efficiency of serum LAMP-2 to predict biochemical response was assessed after 1 year of UDCA treatment in PBC patients by a retrospective analysis. We found that the basal serum LAMP-2 level was increased in PBC, especially in patients with stage III-IV (p = 0.010) or TBIL > 1 mg/dL (p = 0.014). Baseline serum LAMP-2 was higher in non-responders than that in responders, but the difference was statistically insignificant. However, after UDCA treatment, serum LAMP-2 level decreased prominently in the first 3 months, which was more obvious in responders. Further studies showed that the 35% decline of LAMP-2 after treatment for 3 months could be stated as an indicator of UDCA response with the sensitivity of 62.9% and specificity of 75.0% by Paris criteria. Meanwhile the specificity and sensitivity were identified as 63.5% and 64.1% by Barcelona criteria. Together, a decline in LAMP-2 might help to predict the response to UDCA.
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影响因子：
29.4
作者：
Parés, A;Caballería, L;Rodés, J
通讯作者：
Rodés, J
影响因子：
158.5
作者：
POUPON, RE;BALKAU, B;POUPON, R
通讯作者：
POUPON, R
影响因子：
4.2
作者：
Azemoto, Nobuaki;Kumagi, Teru;Onji, Morikazu
通讯作者：
Onji, Morikazu
影响因子：
5.3
作者：
Schneede A;Schmidt CK;Hölttä-Vuori M;Heeren J;Willenborg M;Blanz J;Domanskyy M;Breiden B;Brodesser S;Landgrebe J;Sandhoff K;Ikonen E;Saftig P;Eskelinen EL
通讯作者：
Eskelinen EL
影响因子：
13.5
作者：
Zhang, Li-Na;Shi, Tian-Yan;Zhang, Feng-Chun
通讯作者：
Zhang, Feng-Chun