Is Adolescent E-Cigarette Use Associated With Subsequent Smoking? A New Look.

Is Adolescent E-Cigarette Use Associated With Subsequent Smoking? A New Look.
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DOI:
10.1093/ntr/ntab243
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发表时间:
2022-03-26
期刊:
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子:
--
通讯作者:
Warner KE
Warner KE
中科院分区:
其他
文献类型:
--
作者:
Sun R;Mendez D;Warner KE

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前瞻性研究一直报告说,电子烟的使用与随后吸烟之间存在很强的关联,但许多研究未能对重要的风险因素进行调整。使用人群烟草与健康评估(PATH)研究的纵向数据,我们使用多变量Logistic回归来评估青少年吸电子烟与吸烟的关系,其中四个回归(模型1-4)依次增加了更多的危险因素。我们的样本包括PATH研究的所有波(波1-5)。当添加更多的控制变量时,曾经使用电子烟和随后吸烟之间的关联大幅下降,包括受访者的社会人口学特征、接触烟草者、香烟易感性和行为风险因素。使用最新的数据(波4-4.5和波4.5-5),这种关联在最完整的模型(模型4)中并不显著。使用Wave 4.5-5数据,调整后的优势比从模型1的4.07(95%可信区间[CI,2.86−5.81])下降到模型4的1.35(95%CI,0.84−2.16),模型4调整了所有潜在的危险因素。同样,在模型1中,在所有协变量(模型4)中,曾经使用电子烟和过去30天吸烟的AOR从模型1的3.26(95%CI,1.81−5.86)下降到1.21(95%CI,0.59−2.48)。在青少年从不吸烟的人中,那些在基线上使用过电子烟的人,与从不使用电子烟的人相比,在调整行为风险因素后,在随后的过去12个月或过去30天的吸烟中表现出轻微或不显著的增加。
Prospective studies have consistently reported a strong association between e-cigarette use and subsequent cigarette smoking, but many failed to adjust for important risk factors. Using longitudinal data from the Population Assessment of Tobacco and Health (PATH) Study, we employed multivariable logistic regressions to assess the adolescent vaping-to-smoking relationship, with four regressions (Models 1–4) sequentially adding more risk factors. Our sample included all waves (waves 1–5) of the PATH Study. The association between ever e-cigarette use and subsequent cigarette smoking decreased substantially in magnitude when adding more control variables, including respondents’ sociodemographic characteristics, exposure to tobacco users, cigarette susceptibility, and behavioral risk factors. Using the most recent data (waves 4–4.5 and waves 4.5–5), this association was not significant in the most complete model (Model 4). Using wave 4.5–5 data, the adjusted odds ratio (aOR) for ever e-cigarette use at initial wave and subsequent past 12-month smoking declined from 4.07 (95% confidence interval [CI, 2.86−5.81) in Model 1, adjusting only for sociodemographic characteristics, to 1.35 (95% CI, 0.84−2.16) in Model 4, adjusting for all potential risk factors. Similarly, the aOR of ever e-cigarette use and past 30-day smoking at wave 5 decreased from 3.26 (95% CI, 1.81−5.86) in Model 1 to 1.21 (95% CI, 0.59−2.48) with all covariates (Model 4). Among adolescent never cigarette smokers, those who had ever used e-cigarettes at baseline, compared with never e-cigarette users, exhibited modest or non-significant increases in subsequent past 12-month or past 30-day smoking when adjusting for behavioral risk factors.
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