The roles of microphthalmia-associated transcription factor and pigmentation in melanoma.

The roles of microphthalmia-associated transcription factor and pigmentation in melanoma.
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DOI:
10.1016/j.abb.2014.07.019
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发表时间:
2014-12-01
影响因子:
3.9
通讯作者:
Fisher, David E.
Fisher, David E.
中科院分区:
生物学3区
文献类型:
--
作者:
Hsiao, Jennifer J.;Fisher, David E.

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MITF和色素沉着在正常黑素细胞和转化的黑色素瘤细胞生物学中起重要作用。MITF受多种途径调节,也调节许多靶点,其中一些仍在发现和功能验证中。MITF参与黑素细胞中的广泛过程,包括色素合成和谱系存活。色素沉着本身作为导致黑色素瘤的遗传和环境因素之间的界面起着重要作用。
MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma.
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