Inflammasome in platelets: allying coagulation and inflammation in infectious and sterile diseases?
Inflammasome in platelets: allying coagulation and inflammation in infectious and sterile diseases?
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血小板中的炎性体：传染性和无菌疾病的盟友凝结和炎症？
DOI：
10.1155/2015/435783
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发表时间：
2015
影响因子：
4.6
通讯作者：
Bozza PT
中科院分区：
文献类型：
--
作者：
Hottz ED;Monteiro AP;Bozza FA;Bozza PT
血小板是止血中重要的效应细胞。此外，血小板越来越被认为是主要的炎症细胞，在先天和适应性免疫反应中起着关键作用。在多种凝血障碍和血管病变中，活化血小板具有将凝血与炎症反应联系起来的关键血栓炎性活动。最近发现的血小板炎症活动包括从剪接的前rna合成IL-1β，以及介导IL-1β分泌的炎症小体的存在和组装。在这里，我们回顾了血小板激活翻译机制和炎性小体组装以合成和释放IL-1β的机制。讨论了这些过程对感染性和炎症性疾病的保护性和致病性反应的贡献。
Platelets are crucial effector cells in hemostasis. In addition, platelets are increasingly recognized as major inflammatory cells with key roles in innate and adaptive immune responses. Activated platelets have key thromboinflammatory activities linking coagulation to inflammatory response in a variety of coagulation disorders and vasculopathies. Recently identified inflammatory activities of platelets include the synthesis of IL-1β from spliced pre-RNA, as well as the presence and assembly of inflammasome which intermediate IL-1β secretion. Here we review the mechanisms by which platelets activate translation machinery and inflammasome assembly to synthesize and release IL-1β. The contributions of these processes to protective and pathogenic responses during infectious and inflammatory diseases are discussed.
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影响因子：
29.7
作者：
Davis BK;Wen H;Ting JP
通讯作者：
Ting JP
影响因子：
3
作者：
Campos FM;Franklin BS;Teixeira-Carvalho A;Filho AL;de Paula SC;Fontes CJ;Brito CF;Carvalho LH
通讯作者：
Carvalho LH
影响因子：
20.3
作者：
Andonegui, G;Kerfoot, SM;Kubes, P
通讯作者：
Kubes, P
影响因子：
4.4
作者：
Aggrey, Angela A.;Srivastava, Kalyan;Morrell, Craig N.
通讯作者：
Morrell, Craig N.
影响因子：
4.4
作者：
Hottz, Eugenio D.;Medeiros-de-Moraes, Isabel M.;Bozza, Patricia T.
通讯作者：
Bozza, Patricia T.