Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection.
Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection.
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作者：
肺泡巨噬细胞（Alveolar macrophages， AM）是一种长期存在于气道组织内的先天性免疫细胞。AM是宿主对微生物防御的识别、启动和分解的关键效应物，在介导宿主对肺炎链球菌感染的反应中发挥重要作用。AM的脂质代谢可以显著影响细胞功能和生物学。代谢失调有助于脂质积累、未折叠蛋白反应诱导和炎症细胞因子的产生。本研究旨在探讨Ch25h对肺炎链球菌感染时巨噬细胞介导先天免疫反应的影响。使用野生型和Ch25 - / -小鼠，我们研究了胆固醇代谢对炎症细胞因子产生和细菌清除的作用。我们的研究结果表明，Ch25h在肺炎链球菌感染期间肺部细胞因子和趋化因子产生的起始和强度中起重要作用。在缺乏Ch25h的情况下，细胞吞噬和细菌清除率增强。综上所述，我们的研究结果证明了Ch25h在调节宿主对肺炎链球菌感染的反应性方面的重要作用。
Alveolar macrophages (AM) are long-lived tissue-resident innate immune cells of the airways. AM are key effectors of recognition, initiation, and resolution of the host defense against microbes and play an essential role in mediating host responses to Streptococcus pneumoniae infection. Lipid metabolism in AM can significantly impact cellular function and biology. Dysregulated metabolism contributes to an accumulation of lipids, unfolded protein response induction, and inflammatory cytokine production. Our study was designed to investigate the impact of Ch25h on mediating innate immune responses by macrophages during S. pneumoniae infection. Using wild-type and Ch25−/− mice, we examined the role of cholesterol metabolism on inflammatory cytokine production and bacterial clearance. Our results demonstrate that Ch25h plays an important role in the initiation and intensity of cytokine and chemokine production in the lung during S. pneumoniae infection. In the absence of Ch25h, there was enhanced phagocytosis and bacterial clearance. Taken together, our findings demonstrate the important role of Ch25h in modulating host responsiveness to S. pneumoniae infection.
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影响因子：
32.4
作者：
Blanc M;Hsieh WY;Robertson KA;Kropp KA;Forster T;Shui G;Lacaze P;Watterson S;Griffiths SJ;Spann NJ;Meljon A;Talbot S;Krishnan K;Covey DF;Wenk MR;Craigon M;Ruzsics Z;Haas J;Angulo A;Griffiths WJ;Glass CK;Wang Y;Ghazal P
通讯作者：
Ghazal P
影响因子：
5.3
作者：
Fu, Hang;Spieler, Florian;Loppnow, Harald
通讯作者：
Loppnow, Harald
DOI：
10.1073/pnas.0909142106
发表时间：
2009-09-29
影响因子：
11.1
作者：
Bauman, David R.;Bitmansour, Andrew D.;Russell, David W.
通讯作者：
Russell, David W.
DOI：
10.1073/pnas.1404271111
发表时间：
2014-07-22
影响因子：
11.1
作者：
Gold, Elizabeth S.;Diercks, Alan H.;Aderem, Alan
通讯作者：
Aderem, Alan
影响因子：
3.1
作者：
Phipps, John C.;Aronoff, David M.;Mancuso, Peter
通讯作者：
Mancuso, Peter