Red cells II: acquired anaemias and polycythaemia
Red cells II: acquired anaemias and polycythaemia
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红细胞 II：获得性贫血和红细胞增多症
DOI：
10.1016/s0140-6736(00)02099-7
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
D. Weatherall
中科院分区：
文献类型：
--
作者：
D. Provan;D. Weatherall
•缺铁影响着全球30%的人口。铁的代谢受到严格的调节，肠道运输和储存都是协调的。•由HFE基因突变引起的遗传性血色素病会导致铁吸收增加和多个终末器官损伤。•骨髓增生异常疾病是获得性克隆干细胞疾病，导致红细胞生成无效。再生障碍性贫血是由造血干细胞的内在缺陷引起的；遗传和获得两种形式都有。•原发性红细胞增多症是一种骨髓增生性疾病，是一种非恶性干细胞疾病。
•Iron deficiency affects 30% of the world's population.•Iron metabolism is tightly regulated, with both gut transport and storage being coordinated.•Hereditary haemochromatosis due to mutations in the HFE gene leads to increased absorption of iron and multiple end-organ damage.•Myelodysplastic disorders are acquired clonal stem-cell disorders that cause ineffective erythropoiesis.•Aplastic anaemia is caused by an intrinsic defect of haemopoietic stem cells; both inherited and acquired forms occur.•Primary polycythaemia is a myeloproliferative disorder, a non-malignant stem-cell disease.
影响因子：
20.3
作者：
R. Means;Sanford E. Krantz
通讯作者：
R. Means;Sanford E. Krantz
DOI：
10.1073/pnas.96.4.1579
发表时间：
1999-02
影响因子：
11.1
作者：
A. Waheed;S. Parkkila;J. Saarnio;R. Fleming;Xiao Yan Zhou;S. Tomatsu;R. Britton;B. Bacon;W. Sly
通讯作者：
A. Waheed;S. Parkkila;J. Saarnio;R. Fleming;Xiao Yan Zhou;S. Tomatsu;R. Britton;B. Bacon;W. Sly