Genotypic-specific variance in Caenorhabditis elegans lifetime fecundity.
Genotypic-specific variance in Caenorhabditis elegans lifetime fecundity.
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DOI：
10.1002/ece3.1057
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发表时间：
2014-06
影响因子：
2.6
通讯作者：
Viney, Mark
中科院分区：
文献类型：
--
作者：
Diaz, S. Anaid;Viney, Mark
生物体生活在异质性环境中，因此在这种环境中最大化适应性的策略将会进化。性状的变异很重要，因为它是自然选择在进化过程中作用的原材料。表型变异通常被认为是由于遗传变异和/或环境诱导的影响。因此，在恒定的环境中，基因相同的个体应该具有不变的特征。显然，遗传上相同的个体确实在表型上不同，通常认为这是由于随机过程。现在，特别是从对单细胞物种的研究中，越来越清楚的是，在恒定的环境中，遗传相同的个体之间的表型变异可以受到遗传控制，因此，原则上，这可以受到选择的影响。然而，在多细胞物种中对这些现象的研究很少。在这里，我们研究了平均寿命繁殖力（因此，性状可能是相关的生殖成功），和寿命繁殖力的方差，在最近野生的模式线虫秀丽隐杆线虫分离株。我们发现，这些基因型在一生的繁殖力的方差不同：一些有高的繁殖力的方差，其他非常低的方差。我们发现，这种变化在一生的繁殖力是负相关的平均一生的繁殖力的线，和线的方差是正相关的环境之间。我们认为，在一生的繁殖力的方差可能是一个赌注对冲策略使用的这个物种。
Organisms live in heterogeneous environments, so strategies that maximze fitness in such environments will evolve. Variation in traits is important because it is the raw material on which natural selection acts during evolution. Phenotypic variation is usually thought to be due to genetic variation and/or environmentally induced effects. Therefore, genetically identical individuals in a constant environment should have invariant traits. Clearly, genetically identical individuals do differ phenotypically, usually thought to be due to stochastic processes. It is now becoming clear, especially from studies of unicellular species, that phenotypic variance among genetically identical individuals in a constant environment can be genetically controlled and that therefore, in principle, this can be subject to selection. However, there has been little investigation of these phenomena in multicellular species. Here, we have studied the mean lifetime fecundity (thus a trait likely to be relevant to reproductive success), and variance in lifetime fecundity, in recently-wild isolates of the model nematode Caenorhabditis elegans. We found that these genotypes differed in their variance in lifetime fecundity: some had high variance in fecundity, others very low variance. We find that this variance in lifetime fecundity was negatively related to the mean lifetime fecundity of the lines, and that the variance of the lines was positively correlated between environments. We suggest that the variance in lifetime fecundity may be a bet-hedging strategy used by this species.
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影响因子：
64.8
作者：
Yang, Jian;Loos, Ruth J. F.;Powell, Joseph E.;Medland, Sarah E.;Speliotes, Elizabeth K.;Chasman, Daniel I.;Rose, Lynda M.;Thorleifsson, Gudmar;Steinthorsdottir, Valgerdur;Maegi, Reedik;Waite, Lindsay;Smith, Albert Vernon;Yerges-Armstrong, Laura M.;Monda, Keri L.;Hadley, David;Mahajan, Anubha;Li, Guo;Kapur, Karen;Vitart, Veronique;Huffman, Jennifer E.;Wang, Sophie R.;Palmer, Cameron;Esko, Toenu;Fischer, Krista;Zhao, Jing Hua;Demirkan, Ayse;Isaacs, Aaron;Feitosa, Mary F.;Luan, Jian'an;Heard-Costa, Nancy L.;White, Charles;Jackson, Anne U.;Preuss, Michael;Ziegler, Andreas;Eriksson, Joel;Kutalik, Zoltan;Frau, Francesca;Nolte, Ilja M.;Van Vliet-Ostaptchouk, Jana V.;Hottenga, Jouke-Jan;Jacobs, Kevin B.;Verweij, Niek;Goel, Anuj;Medina-Gomez, Carolina;Estrada, Karol;Bragg-Gresham, Jennifer Lynn;Sanna, Serena;Sidore, Carlo;Tyrer, Jonathan;Teumer, Alexander;Prokopenko, Inga;Mangino, Massimo;Lindgren, Cecilia M.;Assimes, Themistocles L.;Shuldiner, Alan R.;Hui, Jennie;Beilby, John P.;McArdle, Wendy L.;Hall, Per;Haritunians, Talin;Zgaga, Lina;Kolcic, Ivana;Polasek, Ozren;Zemunik, Tatijana;Oostra, Ben A.;Junttila, M. Juhani;Groenberg, Henrik;Schreiber, Stefan;Peters, Annette;Hicks, Andrew A.;Stephens, Jonathan;Foad, Nicola S.;Laitinen, Jaana;Pouta, Anneli;Kaakinen, Marika;Willemsen, Gonneke;Vink, Jacqueline M.;Wild, Sarah H.;Navis, Gerjan;Asselbergs, Folkert W.;Homuth, Georg;John, Ulrich;Iribarren, Carlos;Harris, Tamara;Launer, Lenore;Gudnason, Vilmundur;O'Connell, Jeffrey R.;Boerwinkle, Eric;Cadby, Gemma;Palmer, Lyle J.;James, Alan L.;Musk, Arthur W.;Ingelsson, Erik;Psaty, Bruce M.;Beckmann, Jacques S.;Waeber, Gerard;Vollenweider, Peter;Hayward, Caroline;Wright, Alan F.;Rudan, Igor;Groop, Leif C.;Metspalu, Andres;Khaw, Kay Tee;van Duijn, Cornelia M.;Borecki, Ingrid B.;Province, Michael A.;Wareham, Nicholas J.;Tardif, Jean-Claude;Huikuri, Heikki V.;Cupples, L. Adrienne;Atwood, Larry D.;Fox, Caroline S.;Boehnke, Michael;Collins, Francis S.;Mohlke, Karen L.;Erdmann, Jeanette;Schunkert, Heribert;Hengstenberg, Christian;Stark, Klaus;Lorentzon, Mattias;Ohlsson, Claes;Cusi, Daniele;Staessen, Jan A.;Van der Klauw, Melanie M.;Pramstaller, Peter P.;Kathiresan, Sekar;Jolley, Jennifer D.;Ripatti, Samuli;Jarvelin, Marjo-Riitta;de Geus, Eco J. C.;Boomsma, Dorret I.;Penninx, Brenda;Wilson, James F.;Campbell, Harry;Chanock, Stephen J.;van der Harst, Pim;Hamsten, Anders;Watkins, Hugh;Hofman, Albert;Witteman, Jacqueline C.;Zillikens, M. Carola;Uitterlinden, Andre G.;Rivadeneira, Fernando;Zillikens, M. Carola;Kiemeney, Lambertus A.;Vermeulen, Sita H.;Abecasis, Goncalo R.;Schlessinger, David;Schipf, Sabine;Stumvoll, Michael;Toenjes, Anke;Spector, Tim D.;North, Kari E.;Lettre, Guillaume;McCarthy, Mark I.;Berndt, Sonja I.;Heath, Andrew C.;Madden, Pamela A. F.;Nyholt, Dale R.;Montgomery, Grant W.;Martin, Nicholas G.;McKnight, Barbara;Strachan, David P.;Hill, William G.;Snieder, Harold;Ridker, Paul M.;Thorsteinsdottir, Unnur;Stefansson, Kari;Frayling, Timothy M.;Hirschhorn, Joel N.;Goddard, Michael E.;Visscher, Peter M.
通讯作者：
Visscher, Peter M.
影响因子：
56.9
作者：
Maamar, Hedia;Raj, Arjun;Dubnau, David
通讯作者：
Dubnau, David
影响因子：
3.3
作者：
Hermisson, J;Wagner, GP
通讯作者：
Wagner, GP
DOI：
10.1098/rspb.2013.1104
发表时间：
2013-09-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Viney M;Reece SE
通讯作者：
Reece SE
影响因子：
5.1
作者：
Rae, Robbie;Iatsenko, Igor;Sommer, Ralf J.
通讯作者：
Sommer, Ralf J.