Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects.
Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects.
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Galectin-3 通过直接抗真菌作用影响新型隐球菌感染。
DOI：
10.1038/s41467-017-02126-7
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发表时间：
2017-12-06
影响因子：
16.6
通讯作者：
Casadevall A
中科院分区：
文献类型：
--
作者：
Almeida F;Wolf JM;da Silva TA;DeLeon-Rodriguez CM;Rezende CP;Pessoni AM;Fernandes FF;Silva-Rocha R;Martinez R;Rodrigues ML;Roque-Barreira MC;Casadevall A
Cryptococcus neoformans is an encapsulated fungal pathogen that causes cryptococcosis, which is a major opportunistic infection in immunosuppressed individuals. Mammalian β-galactoside-binding protein Galectin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during microbial infections including some fungal diseases. Here we show that this protein plays a role also in C. neoformans infection. We find augmented Gal-3 serum levels in human and experimental infections, as well as in spleen, lung, and brain tissues of infected mice. Gal-3-deficient mice are more susceptible to cryptococcosis than WT animals, as demonstrated by the higher fungal burden and lower animal survival. In vitro experiments show that Gal-3 inhibits fungal growth and exerts a direct lytic effect on C. neoformans extracellular vesicles (EVs). Our results indicate a direct role for Gal-3 in antifungal immunity whereby this molecule affects the outcome of C. neoformans infection by inhibiting fungal growth and reducing EV stability, which in turn could benefit the host. The protein Galectin-3 modulates host immunity and plays roles during infections. Here, Almeida et al. show that this protein contributes to host defence against infection with the fungal pathogen Cryptococcus neoformans by inhibiting fungal growth and inducing lysis of fungal extracellular vesicles.
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DOI：
10.1038/nrmicro3480
发表时间：
2015-10
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Brown L;Wolf JM;Prados-Rosales R;Casadevall A
通讯作者：
Casadevall A
DOI：
10.1073/pnas.87.18.7324
发表时间：
1990-09-01
影响因子：
11.1
作者：
CHERAYIL, BJ;CHAITOVITZ, S;PILLAI, S
通讯作者：
PILLAI, S
影响因子：
3.1
作者：
Guazzelli, Lorenzo;McCabe, Orla;Oscarson, Stefan
通讯作者：
Oscarson, Stefan
影响因子：
6
作者：
Bernardes, Emerson Soares;Silva, Neide M.;Roque-Barreira, Maria Cristina
通讯作者：
Roque-Barreira, Maria Cristina
影响因子：
4.4
作者：
Jouault, Thierry;Behi, Miryam El Abed-El;Poulain, Daniel
通讯作者：
Poulain, Daniel