Abnormal Baroreflex Control of Heart Rate in Prehypertensive and Hypertensive Dahl Genetically Salt‐Sensitive Rats
Abnormal Baroreflex Control of Heart Rate in Prehypertensive and Hypertensive Dahl Genetically Salt‐Sensitive Rats
复制标题
高血压前期和高血压 Dahl 遗传盐敏感大鼠心率异常压力感受反射控制
作者：
F. Gordon;H. Matsuguchi;A. Mark
本研究验证了在遗传性高血压的Dahl模型中，压力感受性反射功能异常可能先于并促进高血压发展的假设。在喂食高盐或低盐饮食的清醒敏感（S）和抵抗（R）Dahl大鼠中评估压力感受性反射控制心率的敏感性。尽管动脉压与R大鼠没有差异，但低盐喂养的S大鼠压力反射控制心率的敏感性较低。高血压S大鼠的压力感受性反射复位到更高的压力水平，而没有任何进一步的变化的敏感性。与R大鼠相比，在高血压前期和高血压S大鼠中，对苯肾上腺素的升压反应均增强。神经节阻滞消除了这种差异。在高血压S大鼠，神经节阻滞降低动脉压的水平点不同于类似的治疗R大鼠，表明神经原性机制有助于重要的高血压的早期阶段的达尔模型。这些研究已经确定了高血压前期和高血压Dabl S大鼠的压力感受性反射功能受损。这一缺陷增强了对升压刺激的反应，并可能导致Dahl品系中盐诱导的高血压的发展。（高血压3（增刊I）：1-135-1-141，1981）
SUMMARY This study tested the hypothesis that in the Dahl model of genetic hypertension abnormal baroreflex function may precede and contribute to the development of hypertension. Sensitivity of baroreflex control of heart rate was assessed in conscious sensitive (S) and resistant (R) Dahl rats fed a high or low salt diet. Sensitivity of baroreflex control of heart rate was lower in S rats fed low salt although arterial pressure was not different from that of R rats. Hypertensive S rats showed resetting of baroreflexes to the higher pressure level without any further change in sensitivity. Pressor responses to phenylephrine were augmented in both prehypertensive and hypertensive S rats compared to R rats. Ganglionic blockade abolished this difference. In hypertensive S rats, ganglionic blockade decreased arterial pressure to levels Dot different than similarly treated R rats, indicating that neurogenic mechanisms contribute importantly to the early stages of hypertension in the Dahl model. These studies have identified impaired baroreflex function in prehypertensive and hypertensive Dabl S rats. This defect augments responses to pressor stimuli and may contribute to the development of salt-induced hypertension in the Dahl strain. (Hypertension 3 (supp I): 1-135—1-141, 1981)
达尔株遗传性高血压中动脉肌膜特性未改变。
DOI：
10.1152/ajpheart.1981.241.2.h224
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
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作者：
Abel,PW;Trapani,A;Matsuki,N;Ingram,MJ;Ingram,FD;Hermsmeyer,K
通讯作者：
Hermsmeyer,K