The Current Status of Neuroprotection in Congenital Heart Disease.

The Current Status of Neuroprotection in Congenital Heart Disease.
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先天性心脏病的神经保护现状。

DOI:
10.3390/children8121116
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发表时间:
2021-12-02
期刊:
Children (Basel, Switzerland)
影响因子:
--
通讯作者:
Ishibashi N
Ishibashi N
中科院分区:
其他
文献类型:
--
作者:
Kobayashi K;Liu C;Jonas RA;Ishibashi N

文献摘要

参考文献

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神经功能缺损是先天性心脏病(CHD)的严重和常见后遗症。虽然其基本机制尚未得到充分的表征,但其表现是众所周知的,并被理解为在成年期持续存在。开发治疗方法以解决或预防这些缺陷对于降低未来发病率和改善生活质量至关重要。本文就神经保护治疗在冠心病中的应用现状作一综述。通过对患者管理的术前、术中和术后阶段的当前研究的探索,我们将描述现有的临床和实验室工作以及当前在该研究领域正在进行的努力。
Neurological deficits are a serious and common sequelae of congenital heart disease (CHD). While their underlying mechanisms have not been fully characterized, their manifestations are well-known and understood to persist through adulthood. Development of therapies to address or prevent these deficits are critical to attenuate future morbidity and improve quality of life. In this review, we aim to summarize the current status of neuroprotective therapy in CHD. Through an exploration of present research in the pre-operative, intra-operative, and post-operative phases of patient management, we will describe existing clinical and bench efforts as well as current endeavors underway within this research area.
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影响因子: --
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