Evaluation of 4-dimensional computed tomography to 4-dimensional cone-beam computed tomography deformable image registration for lung cancer adaptive radiation therapy.
Evaluation of 4-dimensional computed tomography to 4-dimensional cone-beam computed tomography deformable image registration for lung cancer adaptive radiation therapy.
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评估4维计算机断层扫描对肺癌自适应放射疗法的4维锥束计算机断层扫描图像登记。
DOI：
10.1016/j.ijrobp.2012.12.023
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发表时间：
2013-06-01
影响因子：
7
通讯作者：
Hugo, Geoffrey D.
中科院分区：
文献类型：
--
作者：
Balik, Salim;Weiss, Elisabeth;Jan, Nuzhat;Roman, Nicholas;Sleeman, William C.;Fatyga, Mirek;Christensen, Gary E.;Zhang, Cheng;Murphy, Martin J.;Lu, Jun;Keall, Paul;Williamson, Jeffrey F.;Hugo, Geoffrey D.
目的：评价两种可变形图像配准(DIR)算法在四维锥束计算机断层扫描(4DCBCT)图像引导自适应放射治疗中的应用。对10例局部晚期非小细胞肺癌患者行1次4DFBCT扫描和7次4DCBCT扫描。大体肿瘤体积(GTV)由医生在所有4D图像上勾画。吸气末期计划4DFBCT在每周4DCBCT图像中注册到相应的阶段，用于日常注册。对于阶段到阶段的配准，来自每个4D图像的吸气结束阶段被配准到到期结束阶段。评估了两种DIR算法--小变形逆一致线弹性(SICLE)算法和Insight工具包微分同形恶魔(Demons)算法。使用Dice相似性系数(DSC)、平均对称距离(ASD)、假阳性和假阴性指数比较医生描绘的轮廓和扭曲的轮廓。DIR的结果与肿瘤的刚性配准进行了比较。在日常登记中，肋骨的平均DSC为0.75±0.09，Demons的平均DSC为0.70±0.12，刚性肿瘤的平均DSC为0.66±0.12，刚性骨的平均为0.60±0.14。结果与根据阶段间登记计算的观察者内变异性以及测量的一名患者的观察者间变异性相似。与硬骨(4.1 mm)和硬瘤(3.6 mm)注册相比，Sicle和Demons分别将ASD减少到2.6 mm和3.3 mm。平均而言，SICLE和DEMONS将DSC分别增加到0.80和0.79，而对于4DCBCT阶段到阶段的注册，刚性肿瘤的注册(0.78)。DIR获得了与报告的观察者间描述可变性相当的准确性，并且比刚性肿瘤配准的准确性更高。DIR性能随算法和患者的不同而不同。
To evaluate two deformable image registration (DIR) algorithms for the purpose of contour mapping to support image guided adaptive radiotherapy with four-dimensional cone beam computed tomography (4DCBCT). One planning 4D fan-beam CT (4DFBCT) and 7 weekly 4DCBCT scans were acquired for 10 locally advanced non-small cell lung cancer patients. The gross tumor volume (GTV) was delineated by a physician in all 4D images. End-of-inspiration phase planning 4DFBCT was registered to the corresponding phase in weekly 4DCBCT images for day-to-day registrations. For phase-to-phase registration, the end-of-inspiration phase from each 4D image was registered to the end-of-expiration phase. Two DIR algorithms—small deformation inverse consistent linear elastic (SICLE) and Insight Toolkit diffeomorphic demons (DEMONS)—were evaluated. Physician-delineated contours were compared to the warped contours by using the Dice similarity coefficient (DSC), average symmetric distance (ASD), false positive and false negative indices. The DIR results are compared to rigid registration of tumor. For day-to-day registrations, the mean DSC was 0.75 ± 0.09 with SICLE, 0.70 ± 0.12 with DEMONS, 0.66 ± 0.12 with rigid-tumor registration and 0.60 ± 0.14 with rigid-bone registration. Results were comparable to intra-observer variability calculated from phase-to-phase registrations as well as measured inter-observer variation for one patient. SICLE and DEMONS, when compared to rigid-bone (4.1 mm) and rigid-tumor (3.6 mm) registration, respectively reduced the ASD to 2.6 and 3.3 mm. On average, SICLE and DEMONS increased the DSC to 0.80 and 0.79 respectively, compared to rigid-tumor (0.78) registrations for 4DCBCT phase-to-phase registrations. DIR achieved comparable accuracy to reported inter-observer delineation variability and higher accuracy than rigid-tumor registration. DIR performance varied with the algorithm and the patient.
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DOI：
10.1016/j.ijrobp.2010.11.032
发表时间：
2011-10-01
影响因子：
7
作者：
Hugo, Geoffrey D.;Weiss, Elisabeth;Badawi, Ahmed;Orton, Matthew
通讯作者：
Orton, Matthew
影响因子：
3.8
作者：
Hou, Jidong;Guerrero, Mariana;D'Souza, Warren D.
通讯作者：
D'Souza, Warren D.
影响因子：
5.7
作者：
Speight, Richard;Sykes, Jonathan;Thwaites, David
通讯作者：
Thwaites, David
DOI：
10.1016/j.ijrobp.2008.07.063
发表时间：
2009-06-01
影响因子：
7
作者：
Fox, Jana;Ford, Eric;Song, Danny Y.
通讯作者：
Song, Danny Y.
影响因子：
4.8
作者：
DICE, LR
通讯作者：
DICE, LR