Heat Shock Proteins and Ferroptosis.
Heat Shock Proteins and Ferroptosis.
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DOI：
10.3389/fcell.2022.864635
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
铁死亡是 Dixon 于 2012 年命名的一种新形式的调节性细胞死亡，其特征是脂质过氧化物和铁离子的积累。分子伴侣是细胞质中一类进化保守的蛋白质。它们识别并结合不完全折叠或组装的蛋白质，以帮助它们折叠、运输或防止它们聚集，但它们本身不参与最终产品的形成。作为数量最多的分子伴侣，热休克蛋白可分为五个家族：HSP110（HSPH）、HSP90（HSPC）、HSP70（HSPA）、HSP40（DNAJ）和小热休克蛋白（HSPB）。不同的热休克蛋白在不同疾病中促进或抑制铁死亡中发挥不同的作用。已知铁死亡参与肿瘤、神经系统疾病、肾损伤和缺血再灌注损伤。然而，关于热休克蛋白与铁死亡关系的综述很少。本研究系统总结了热休克蛋白在铁死亡发生中的作用，并预测了不同家族热休克蛋白在铁死亡发生过程中的可能机制。
Ferroptosis is a new form of regulatory cell death named by Dixon in 2012, which is characterized by the accumulation of lipid peroxides and iron ions. Molecular chaperones are a class of evolutionarily conserved proteins in the cytoplasm. They recognize and bind incompletely folded or assembled proteins to help them fold, transport or prevent their aggregation, but they themselves do not participate in the formation of final products. As the largest number of molecular chaperones, heat shock proteins can be divided into five families: HSP110 (HSPH), HSP90 (HSPC), HSP70 (HSPA), HSP40 (DNAJ) and small heat shock proteins (HSPB). Different heat shock proteins play different roles in promoting or inhibiting ferroptosis in different diseases. It is known that ferroptosis is participated in tumors, nervous system diseases, renal injury and ischemia-reperfusion injury. However, there are few reviews about the relationship of heat shock proteins and ferroptosis. In this study, we systematically summarize the roles of heat shock proteins in the occurrence of ferroptosis, and predict the possible mechanisms of different families of heat shock proteins in the development of ferroptosis.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
8.4
作者：
Dikic, Ivan;Crosetto, Nicola;Bernasconi, Paolo
通讯作者：
Bernasconi, Paolo
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M
影响因子：
20.3
作者：
Canli, Oezge;Alankus, Yasemin B.;Greten, Florian R.
通讯作者：
Greten, Florian R.