Numerical study for blood flow in pulmonary arteries after repair of tetralogy of Fallot.
Numerical study for blood flow in pulmonary arteries after repair of tetralogy of Fallot.
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DOI：
10.1155/2012/198108
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发表时间：
2012
影响因子：
--
通讯作者：
Her SW
中科院分区：
文献类型：
--
作者：
Chern MJ;Wu MT;Her SW
肺动脉瓣返流（PR）是法洛四联症（TOF）术后患者肺动脉内的常见现象。临床资料显示，左肺动脉（LPA）的返流分数通常大于右肺动脉（RPA）。可能与肺动脉血流有关。因此，了解肺动脉血流动力学有助于理解其原因。本研究的目的是使用3D重建的肺动脉模型，磁共振成像（MRI）和使用数值方法模拟肺动脉的血流变化后修复TOF。从数值结果来看，肺动脉分叉角度和几何形状对血流有一定的影响。由于LPA与主肺动脉（MPA）的夹角较小，TOF修复后LPA首先发生返流。在收缩加速时，在LPA中发现了阻碍血液向前流动到左肺的再循环区域。分析了压力分布，压力极值变化主要发生在MPA的膨胀区。将MPA、LPA和RPA中包括返流的数值数据与相位对比MR测量数据进行比较。数值计算结果与实测数据吻合较好。
Pulmonary regurgitation (PR) is a common phenomenon in pulmonary arteries in patients after repair of tetralogy of Fallot (TOF). The regurgitation fraction of left pulmonary artery (LPA) is usually greater than right pulmonary artery (RPA) according to clinic data. It may be related to blood flow in pulmonary arteries. Therefore, understanding hemodynamics in pulmonary arteries helps to comprehend the reason. The aim of this study is to use 3D reconstructed pulmonary artery models from magnetic resonance imaging (MRI) and to use numerical approaches for simulation of flow variations in pulmonary arteries after repair of TOF. From the numerical results, the blood flow is influenced by the bifurcation angles and geometry of pulmonary artery. The regurgitation happens first in LPA after repair of TOF due to the small angle between LPA and main pulmonary artery (MPA). The recirculation region which obstructs forward blood flow to the left lung is found in LPA during acceleration of systole. We also analyze the pressure distribution; the extreme pressure variations are in dilation area of MPA. Numerical data including regurgitation in MPA, LPA, and RPA are compared with phase contrast MR measured data. Good agreements are found between numerical results and measured data.
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