Elevated C-reactive protein is associated with lower increase in knee muscle strength in patients with knee osteoarthritis: a 2-year follow-up study in the Amsterdam Osteoarthritis (AMS-OA) cohort.
Elevated C-reactive protein is associated with lower increase in knee muscle strength in patients with knee osteoarthritis: a 2-year follow-up study in the Amsterdam Osteoarthritis (AMS-OA) cohort.
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DOI：
10.1186/ar4580
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发表时间：
2014-06-13
影响因子：
4.9
通讯作者：
Lems WF
中科院分区：
文献类型：
--
作者：
Sanchez-Ramirez DC;van der Leeden M;van der Esch M;Roorda LD;Verschueren S;van Dieën JH;Dekker J;Lems WF
本研究旨在探讨膝关节骨关节炎(OA)患者发病2年后血清C-反应蛋白(CRP)和血沉(ESR)升高与肌力变化的关系。收集186例膝骨性关节炎患者在基线和2年随访时的数据。从患者的血液中检测血清中的C反应蛋白(毫克/升)和血沉(毫米/小时)。使用等速测力仪评估股四头肌和腿筋肌的力量。采用单变量和多变量线性回归模型分析炎症标志物与膝关节肌力变化的关系。C反应蛋白水平在基线和2年随访期间均升高的患者在2年期间膝关节肌力的增幅低于在两个评估时间内未升高水平的患者(β = -0.22；P = 0.01)。在对相关混杂因素进行调整后，这种关联仍然存在。两次评估时血沉的升高与膝关节肌力的变化无显著相关性(β = -0.0 5；P = 0.49)。我们的结果表明，在确诊的膝骨性关节炎患者中，升高的CRP值与随时间推移的肌力增加较低有关。尽管解释这种关系的机制尚未完全阐明，但这些结果表明炎症是影响这类患者肌肉力量的相关因素。
The aim of this study was to examine the associations of elevated serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) with change in muscle strength in patients with established knee osteoarthritis (OA), at 2 years. Data from 186 patients with knee OA were gathered at baseline and at 2-year follow-up. CRP (in milligrams per liter) and ESR (in millimeters per hour) were measured in serum from patients’ blood. Strength of quadriceps and hamstrings muscles was assessed by using an isokinetic dynamometer. The association of inflammatory markers with change in knee muscle strength was analyzed by using uni- and multi-variate linear regression models. Patients with elevated CRP values at both baseline and 2-year follow-up exhibited a lower increase in knee muscle strength for a period of 2 years (β = -0.22; P = 0.01) compared with the group with non-elevated levels at both times of assessment. The association persisted after adjustment for relevant confounders. Elevated ESR values at both times of assessment were not significantly associated with change in knee muscle strength (β = -0.05; P = 0.49). Our results indicate that elevated CRP values are related to a lower gain in muscle strength over time in patients with established knee OA. Although the mechanism to explain this relationship is not fully elucidated, these results suggest inflammation as a relevant factor influencing muscle strength in this group of patients.
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DOI：
10.1155/2012/560634
发表时间：
2012
期刊：
Arthritis
影响因子：
--
作者：
Dean E;Gormsen Hansen R
通讯作者：
Gormsen Hansen R
影响因子：
27.4
作者：
O'Reilly, SC;Jones, A;Doherty, M
通讯作者：
Doherty, M
影响因子：
7
作者：
Pearle, A. D.;Scanzello, C. R.;Crow, M. K.
通讯作者：
Crow, M. K.
影响因子：
2.2
作者：
PRICE, CP;TRULL, AK;GORMAN, EG
通讯作者：
GORMAN, EG
DOI：
10.1111/j.1532-5415.1968.tb02103.x
发表时间：
1968-01-01
影响因子：
6.3
作者：
LINN, BS;LINN, MW;GUREL, L
通讯作者：
GUREL, L