Population Estimates of GFR and Risk Factors for CKD in Guatemala.
Population Estimates of GFR and Risk Factors for CKD in Guatemala.
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DOI：
10.1016/j.ekir.2020.12.015
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发表时间：
2021-03
影响因子：
6
通讯作者：
Rohloff P
中科院分区：
文献类型：
--
作者：
Miller AC;Tuiz E;Shaw L;Flood D;Garcia P;Dhaenens E;Thomson DR;Barnoya J;Montano CM;Rohloff P
慢性肾脏疾病（CKD）是中美洲新兴的公共卫生重点。然而，关于中美洲人口最多的国家危地马拉慢性肾病患病率的数据有限，特别是在农村社区。我们对危地马拉的两个农村农业城市进行了具有人口代表性的调查。我们收集了人体测量数据、血压、血清和尿肌酐、糖化血红蛋白和尿白蛋白。社会人口学、健康和暴露数据均为自我报告。我们招募了807名个体（63%符合条件，35%为男性，平均年龄39.5岁）。估计4.0%（95%置信区间[CI] 2.4-6.6）患有CKD，定义为肾小球滤过率（eGFR）低于60ml /min / 1.73 m2。大多数eGFR低于60 ml/min / 1.73 m2的个体患有糖尿病或高血压。在多变量分析中，与eGFR低于60 ml/min / 1.73 m2相关的重要因素包括糖尿病或高血压史（调整比值比[aOR] 11.21; 95% CI 3.28-38.24）、体重过轻（体重指数[BMI] <18.5） （aOR 21.09; 95% CI 2.05-217.0）以及甘蔗农业与贫困之间的相互作用（aOR 1.10; 95% CI 1.01-1.19）。在这项基于人群的调查中，大多数观察到的CKD与糖尿病和高血压有关。这些结果强调了解决危地马拉农村地区糖尿病、高血压和慢性肾病流行的迫切公共卫生需要。此外，贫困人群CKD与甘蔗的相关性为研究社区存在病因不明的CKD提供了一些间接证据，这需要进一步的调查。
Chronic kidney disease (CKD) is an emerging public health priority in Central America. However, data on the prevalence of CKD in Guatemala, Central America’s most populous country, are limited, especially for rural communities. We conducted a population-representative survey of 2 rural agricultural municipalities in Guatemala. We collected anthropometric data, blood pressure, serum and urine creatinine, glycosylated hemoglobin, and urine albumin. Sociodemographic, health, and exposure data were self-reported. We enrolled 807 individuals (63% of all eligible, 35% male, mean age 39.5 years). An estimated 4.0% (95% confidence interval [CI] 2.4–6.6) had CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min per 1.73 m2. Most individuals with an eGFR below 60 ml/min per 1.73 m2 had diabetes or hypertension. In multivariable analysis, the important factors associated with risk for an eGFR less than 60 ml/min per 1.73 m2 included a history of diabetes or hypertension (adjusted odds ratio [aOR] 11.21; 95% CI 3.28–38.24), underweight (body mass index [BMI] <18.5) (aOR 21.09; 95% CI 2.05–217.0), and an interaction between sugar cane agriculture and poverty (aOR 1.10; 95% CI 1.01–1.19). In this population-based survey, most observed CKD was associated with diabetes and hypertension. These results emphasize the urgent public health need to address the emerging epidemic of diabetes, hypertension, and CKD in rural Guatemala. In addition, the association between CKD and sugar cane in individuals living in poverty provides some circumstantial evidence for existence of CKD of unknown etiology in the study communities, which requires further investigation.
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影响因子：
6
作者：
Garcia, Pablo;Mendoza, Carlos;Rohloff, Peter
通讯作者：
Rohloff, Peter
DOI：
10.1111/obr.12571
发表时间：
2017-07
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Corvalán C;Garmendia ML;Jones-Smith J;Lutter CK;Miranda JJ;Pedraza LS;Popkin BM;Ramirez-Zea M;Salvo D;Stein AD
通讯作者：
Stein AD
影响因子：
2.3
作者：
Caplin B;Jakobsson K;Glaser J;Nitsch D;Jha V;Singh A;Correa-Rotter R;Pearce N
通讯作者：
Pearce N
影响因子：
13.2
作者：
Gallo-Ruiz, Lyanne;Sennett, Caryn M.;Scammell, Madeleine K.
通讯作者：
Scammell, Madeleine K.
影响因子：
2.3
作者：
Flood, David;Wilcox, Katharine;Chary, Anita
通讯作者：
Chary, Anita