International Collaboration for the Epidemiology of eGFR in Low and Middle Income Populations - Rationale and core protocol for the Disadvantaged Populations eGFR Epidemiology Study (DEGREE).
International Collaboration for the Epidemiology of eGFR in Low and Middle Income Populations - Rationale and core protocol for the Disadvantaged Populations eGFR Epidemiology Study (DEGREE).
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DOI：
10.1186/s12882-016-0417-1
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发表时间：
2017-01-03
期刊：
影响因子：
2.3
通讯作者：
Pearce N
中科院分区：
文献类型：
--
作者：
Caplin B;Jakobsson K;Glaser J;Nitsch D;Jha V;Singh A;Correa-Rotter R;Pearce N
在低收入和中等收入国家(LMIC)的农业社区中，人们越来越多地认识到主要是管状-间质性慢性肾脏病(CKD)聚集性的流行。虽然目前尚不清楚是否存在统一的潜在病因，但这些情况已被统称为不明原因的CKD(CKDu)。据估计，在过去的20年里，CKDu导致了数万到数十万年轻男女的过早死亡。因此，迫切需要了解这些疾病的病因和病理生理学(S)。国际比较为了解许多慢性疾病提供了第一步，但这种比较依赖于估计疾病流行率的标准化工具的可用性。这是CKD的一个特殊问题，因为这种疾病直到晚期都是无症状的，而且在人群研究中用于估计肾小球滤过率(GFR)的方法所固有的偏差在不同人群中是高度不同的。因此，我们提出了一个简单的标准化方案来估计GFR在LMIC人群中的分布--弱势人群EGFR流行病学(度)研究。这包括对具有代表性的成人人群样本中的肾功能进行量化，以及对血肌酐测量进行标准化的要求，以及储存样本以供将来测量胱抑素C和确定对身体成分的估计，以便对人群内和人群之间估计的GFR(EGFR)进行有效的比较。我们提出的方法可能适用于任何地方，但我们特别关注LMIC中的弱势人群，因为他们似乎最容易受到CKDu的影响。虽然该方案也可用于特定群体(例如，被认为存在CKDU过度风险的职业群体)，但学位项目的主要目的是描述EGFR在多个地区的人口分布，以便进行国际比较。只有通过标准化的方法，才有可能估计受影响地区之间肾功能受损的规模和差异。然后，这些数据将提供对这种日益被认识的疾病的重要社会、人口和环境风险因素的洞察。本文的在线版本(doi：10.1186/s12882-0160417-1)包含补充材料，授权用户可以使用。
There is an increasing recognition of epidemics of primarily tubular-interstitial chronic kidney disease (CKD) clustering in agricultural communities in low- and middle-income countries (LMICs). Although it is currently unclear whether there is a unified underlying aetiology, these conditions have been collectively termed CKD of undetermined cause (CKDu). CKDu is estimated to have led to the premature deaths of tens to hundreds of thousands of young men and women over the last 2 decades. Thus, there is an urgent need to understand the aetiology and pathophysiology of these condition (s). International comparisons have provided the first steps in understanding many chronic diseases, but such comparisons rely on the availability of standardised tools to estimate disease prevalence. This is a particular problem with CKD, since the disease is asymptomatic until the late stages, and the biases inherent in the methods used to estimate the glomerular filtration rate (GFR) in population studies are highly variable across populations. We therefore propose a simple standardised protocol to estimate the distribution of GFR in LMIC populations – The Disadvantaged Populations eGFR Epidemiology (DEGREE) Study. This involves the quantification of renal function in a representative adult population-based sample and a requirement for standardisation of serum creatinine measurements, along with storage of samples for future measurements of cystatin C and ascertainment of estimates of body composition, in order to obtain valid comparisons of estimated GFR (eGFR) within and between populations. The methodology we present is potentially applicable anywhere, but our particular focus is on disadvantaged populations in LMICs, since these appear to be most susceptible to CKDu. Although the protocol could also be used in specific groups (e.g. occupational groups, thought to be at excess risk of CKDu) the primary aim of the DEGREE project is characterise the population distribution of eGFR in multiple regions so that international comparisons can be performed. It is only with a standardised approach that it will be possible to estimate the scale of, and variation in, impaired kidney function between affected areas. These data should then provide insights into important social, demographic and environmental risk factors for this increasingly recognised disease. The online version of this article (doi:10.1186/s12882-016-0417-1) contains supplementary material, which is available to authorized users.
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影响因子：
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作者：
Seck SM;Doupa D;Gueye L;Dia CA
通讯作者：
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影响因子：
168.9
作者：
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通讯作者：
Rajapurkar MM
影响因子：
4.9
作者：
Wells, J. C. K.;Williams, J. E.;Cole, T. J.
通讯作者：
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