Gender differences in short-term effects of atorvastatin on lipid profile, fibrinolytic parameters, and endothelial function.
Gender differences in short-term effects of atorvastatin on lipid profile, fibrinolytic parameters, and endothelial function.
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阿托伐他汀对血脂、纤溶参数和内皮功能的短期影响存在性别差异。
DOI：
10.1016/j.numecd.2006.10.008
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Y. Tamura
中科院分区：
文献类型：
--
作者：
K. Sakabe;N. Fukuda;Yamato Fukuda;K. Wakayama;T. Nada;S. Morishita;H. Shinohara;Y. Tamura
背景和目的 关于性别对阿托伐他汀短期效果的影响知之甚少。我们调查了阿托伐他汀治疗的短期降脂和多效性作用的性别差异。方法和结果72 名连续患者（包括 48 名患有原发性高胆固醇血症的女性）被前瞻性地分配接受阿托伐他汀（10 毫克/天）治疗 3 个月。我们在基线和治疗 3 个月后测量了空腹脂质浓度、作为脂质过氧化物标志物的硫代巴比妥酸反应物质 (TBARS)、纤溶参数以及通过肱动脉血流介导的血管舒张 (FMD) 的内皮功能。我们评估了性别对这些参数的时间差异的影响。在男性中，阿托伐他汀可降低总低密度脂蛋白 (LDL) 和小密度 LDL 胆固醇浓度，并在 3 个月后增加 FMD。在女性中，阿托伐他汀降低了 TBARS、甘油三酯、总胆固醇、低密度脂蛋白、小而密的低密度脂蛋白和残余脂蛋白颗粒胆固醇浓度，并在 3 个月后增加了 FMD。无论男性还是女性，纤溶参数均无显着变化。就3个月后这些参数的百分比变化而言，女性的TBARS（-17.6±12.4 vs. -0.4±18.8%，p<0.01）和小而密的LDL胆固醇（-96.7±8.3 vs. -68.6±29.7%，p<0.01）下降幅度更大，尽管男性和女性之间其他参数的相对变化相似。结论我们发现，短期阿托伐他汀治疗后，一些血脂改变的变化存在性别差异，包括 TBARS 和低密度低密度脂蛋白胆固醇浓度，其中女性的差异更大。然而，短期阿托伐他汀治疗可能有利于改善男性和女性的内皮功能。
BACKGROUND AND AIMLittle is known about the impact of gender on short-term effects of atorvastatin. We investigated the gender differences in the short-term lipid-lowering and pleiotropic effects of atorvastatin therapy.METHODS AND RESULTSSeventy-two consecutive patients including 48 women with primary hypercholesterolemia, were assigned prospectively to treatment with atorvastatin (10mg/day) for 3months. We measured fasting lipid concentrations, thiobarbituric acid reactive substances (TBARS) as marker of lipid peroxide, fibrinolytic parameters, and endothelial function by flow-mediated vasodilation of the brachial artery (FMD), at baseline and after 3months of therapy. We assessed the impact of gender on temporal differences in these parameters. In men, atorvastatin decreased total, low-density lipoprotein (LDL), and small, dense LDL-cholesterol concentrations, and increased FMD after 3months. In women, atorvastatin decreased TBARS, triglyceride, and total, LDL, small, dense LDL, and remnant-like lipoprotein particle-cholesterol concentrations, and increased FMD after 3months. Fibrinolytic parameters did not change significantly in either men or women. With respect to the percent change in those parameters after 3months, TBARS (−17.6±12.4 vs. −0.4±18.8%, p<0.01) and small, dense LDL-cholesterol (−96.7±8.3 vs. −68.6±29.7%, p<0.01) decreased to a greater degree in women, although the relative changes in other parameters were similar between men and women.CONCLUSIONSWe found gender differences in some of the lipid altering changes, including TBARS and small, dense LDL-cholesterol concentrations, after short-term atorvastatin therapy, which were greater in women. However, short-term atorvastatin therapy may be beneficial in improving endothelial function equally in both men and women.
影响因子：
5.3
作者：
Pedro-Botet, J;Schaefer, EJ;Ordovas, JM
通讯作者：
Ordovas, JM
影响因子：
5
作者：
Kamigaki, AS;Siscovick, DS;Austin, MA
通讯作者：
Austin, MA