Autophagy: cellular and molecular mechanisms.
Autophagy: cellular and molecular mechanisms.
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DOI：
10.1002/path.2697
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发表时间：
2010-05
影响因子：
7.3
通讯作者：
Macleod, Kay F.
中科院分区：
文献类型：
--
作者：
Glick, Danielle;Barth, Sandra;Macleod, Kay F.
自噬是一种自我降解的过程，对于在发育的关键时期平衡能量来源和应对营养胁迫非常重要。自噬还在去除错误折叠或聚集的蛋白质，清除受损的细胞器（如线粒体、内质网和过氧化物酶体）以及消除细胞内病原体中发挥管家作用。因此，自噬通常被认为是一种生存机制，尽管其失调与非凋亡性细胞死亡有关。自噬可以是非选择性的，也可以是选择性的，可以去除特定的细胞器、核糖体和蛋白质聚集体，尽管选择性自噬的调节机制还没有完全阐明。除了消除细胞内聚集体和受损的细胞器外，自噬还促进细胞衰老和细胞表面抗原呈递，防止基因组不稳定性并防止坏死，使其在预防癌症，神经变性，心肌病，糖尿病，肝病，自身免疫性疾病和感染等疾病中发挥关键作用。本文综述了自噬如何在分子水平上执行和调节以及其破坏如何导致疾病的最新研究结果。
Autophagy is a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating intracellular pathogens. Thus, autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy can be either non-selective or selective in the removal of specific organelles, ribosomes and protein aggregates, although the mechanisms regulating aspects of selective autophagy are not fully worked out. In addition to elimination of intracellular aggregates and damaged organelles, autophagy promotes cellular senescence and cell surface antigen presentation, protects against genome instability and prevents necrosis, giving it a key role in preventing diseases such as cancer, neurodegeneration, cardiomyopathy, diabetes, liver disease, autoimmune diseases and infections. This review summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease.
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
50.3
作者：
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ATG32是一种线粒体蛋白，在线粒体过程中赋予了选择性。
影响因子：
11.8
作者：
Kanki, Tomotake;Wang, Ke;Cao, Yang;Baba, Misuzu;Klionsky, Daniel J.
通讯作者：
Klionsky, Daniel J.