Birth prevalence and natural history of congenital cytomegalovirus infection in a highly seroimmune population.
Birth prevalence and natural history of congenital cytomegalovirus infection in a highly seroimmune population.
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DOI：
10.1086/600882
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发表时间：
2009-08-15
期刊：
影响因子：
--
通讯作者：
Britt WJ
中科院分区：
文献类型：
--
作者：
Mussi-Pinhata MM;Yamamoto AY;Moura Brito RM;de Lima Isaac M;de Carvalho e Oliveira PF;Boppana S;Britt WJ
先天性巨细胞病毒感染的自然史在母体巨细胞病毒血清阳性率高的人群中知之甚少。本研究评估了出生患病率，出生时的临床表现，以及来自此类人群的感染儿童的听力结果。连续出生的婴儿在前两周内接受尿液和/或唾液中是否存在巨细胞病毒的筛查。记录新生儿的临床表现，并对感染儿童进行测试，以记录随访期间的听力功能。一个子集的母亲感染的婴儿进行产前检测抗CMV IgG抗体的存在。8047名婴儿中有87名被确认为先天性CMV感染（1.08%; 95%CI：0.86-1.33）。七个（8.1%; 95%可信区间：3.3-15.9）例婴儿至少有一项提示CMV感染的临床结果，4例（4.6%; CI 95%：1.3-11.3）例婴儿有≥ 3项全身性疾病结果。5/58（8.6%; CI 95%：2.9-19.0）例中位年龄为21个月的受试儿童发现感音神经性听力损失。在两名儿童中观察到双侧极重度听力损失，所有五名听力损失儿童的听力阈值>60 dBHL，包括两名母亲可能患有非原发性CMV感染的儿童。在CMV血清免疫力高的人群中进行的第一次大型新生儿筛查研究的结果提供了额外的证据，表明先天性CMV疾病发生在血清阳性率高的人群中，CMV相关听力损失的发病率与发达国家人群中CMV血清免疫力较低的女性的后代相似。
The natural history of congenital CMV infection is scarcely known in populations with high maternal CMV seroprevalence. This study evaluated birth prevalence, clinical findings at birth, and hearing outcome in infected children from such a population. Infants consecutively born were screened for the presence of CMV in urine and/or saliva within the first two weeks. Neonatal clinical findings were recorded and infected children were tested to document hearing function during follow-up. A subset of mothers of infected infants was prenatally tested for the presence of anti-CMV IgG antibodies. Congenital CMV infection was confirmed in 87/8047 infants (1.08%; 95%CI: 0.86–1.33). Seven (8.1%; 95%CI: 3.3–15.9) infants had at least one clinical finding suggestive of CMV infection and 4 (4.6%; CI95%: 1.3–11.3) had ≥ 3 findings of systemic disease. Sensorineural hearing loss was found in 5/58 (8.6%; CI95%: 2.9–19.0) children tested at a median age of 21 months. Bilateral profound hearing loss was observed in two children and hearing threshold was >60 dBHL in all five children with hearing loss, including two children born to mothers with probable non primary CMV infection. The results of this first large newborn screening study in a population with high CMV seroimmunity provide additional evidence that congenital CMV disease occurs in populations with high seroprevalence rates with a similar incidence of CMV-related hearing loss to that reported in offspring of women from populations in the developed countries with lower rates of seroimmunity to CMV.
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影响因子：
3.6
作者：
BOPPANA, SB;PASS, RF;ALFORD, CA
通讯作者：
ALFORD, CA
DOI：
10.1128/cdli.4.4.469-473.1997
发表时间：
1997-07-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Lazzarotto, T;Spezzacatena, P;Landini, MP
通讯作者：
Landini, MP
影响因子：
1.1
作者：
MONTGOMERY, JR;MASON, EO;SOUTH, MA
通讯作者：
SOUTH, MA
影响因子：
3.6
作者：
BERGE, P;STAGNO, S;ARMSTRONG, D
通讯作者：
ARMSTRONG, D
影响因子：
8
作者：
Lazzarotto, T;Gabrielli, L;Landini, MP
通讯作者：
Landini, MP