Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrus.
Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrus.
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DOI：
10.1016/j.brainres.2010.01.084
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发表时间：
2010-04-06
期刊：
影响因子：
2.9
通讯作者：
Day, Heidi E. W.
中科院分区：
文献类型：
--
作者：
Campeau, Serge;Nyhuis, Tara J.;Kryskow, Elisabeth M.;Masini, Cher V.;Babb, Jessica A.;Sasse, Sarah K.;Greenwood, Benjamin N.;Fleshner, Monika;Day, Heidi E. W.
海马结构是一个高度可塑性的大脑区域，对压力很敏感。它接收广泛的去甲肾上腺素能投射，并且海马体释放去甲肾上腺素以应对压力源暴露。海马体表达特别高水平的 α1D 肾上腺素能受体 (ADR)，我们之前已经证明大鼠海马体中的 α1d ADR mRNA 表达受皮质酮调节。应激反应的决定性特征之一是下丘脑垂体肾上腺 (HPA) 轴的激活，导致肾上腺释放皮质酮。然而，应激对海马α1d ADR mRNA表达的影响尚未确定。在本研究中，雄性大鼠受到不可避免的尾部电击、大声噪音或束缚，通过半定量原位杂交测定对海马α1d ADR mRNA表达的影响。所有三种应激源均导致齿状回中 α1d ADR mRNA 快速上调，表达在应激源开始后约 90 分钟达到峰值。此前曾有报道称，体力活动可以抵消齿状回内发生的一些压力影响。然而，大鼠自愿跑轮6周并不能阻止束缚应激引起的齿状回α1d ADR mRNA表达的增加。尽管齿状回中 α1D ADR 的功能尚不清楚，但这些数据为压力与海马去甲肾上腺素能系统之间的密切相互作用提供了进一步的证据。
The hippocampal formation is a highly plastic brain region that is sensitive to stress. It receives extensive noradrenergic projections, and noradrenaline is released in the hippocampus in response to stressor exposure. The hippocampus expresses particularly high levels of the α1D adrenergic receptor (ADR) and we have previously demonstrated that α1d ADR mRNA expression in the rat hippocampus is modulated by corticosterone. One of the defining features of a stress response is activation of the hypothalamic pituitary adrenal (HPA) axis, resulting in the release of corticosterone from the adrenal glands. However, the effect of stress on hippocampal expression of α1d ADR mRNA has not been determined. In this study, male rats were exposed to inescapable tail shock, loud noise or restraint, and the effect on α1d ADR mRNA expression in the hippocampus was determined by semi-quantitative in situ hybridization. All three stressors resulted in a rapid upregulation of α1d ADR mRNA in the dentate gyrus, with expression peaking at approximately 90 minutes after the start of the stressor. Physical activity has previously been reported to counteract some of the effects of stress that occur within the dentate gyrus. However, 6 weeks of voluntary wheel running in rats did not prevent the restraint stress-induced increase in α1d ADR mRNA expression in the dentate gyrus. Although the function of the α1D ADR in the dentate gyrus is not known, these data provide further evidence for a close interaction between stress and the noradrenergic system in the hippocampus.
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影响因子：
3.3
作者：
Fediuc, Sergiu;Campbell, Jonathan E.;Riddell, Michael C.
通讯作者：
Riddell, Michael C.
影响因子：
2.9
作者：
MACCARI, S;LEMOAL, M;MORMEDE, P
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MORMEDE, P
DOI：
10.1152/ajpregu.00513.2002
发表时间：
2003-02-01
影响因子：
2.8
作者：
Campisi, J;Leem, TH;Fleshner, M
通讯作者：
Fleshner, M
影响因子：
3.4
作者：
Day, HEW;Nebel, S;Campeau, S
通讯作者：
Campeau, S
影响因子：
3.2
作者：
Droste, S. K.;Schweizer, M. C.;Reul, J. M. H. M.
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Reul, J. M. H. M.