Near-infrared fluorescent nanoGUMBOS for biomedical imaging.
Near-infrared fluorescent nanoGUMBOS for biomedical imaging.
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DOI:
10.1021/nn9010126
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发表时间:
2009-12-22
期刊:
影响因子:
17.1
通讯作者:
Warner IM
中科院分区:
文献类型:
--
作者:
Bwambok DK;El-Zahab B;Challa SK;Li M;Chandler L;Baker GA;Warner IM
Herein, we report on near infrared (NIR) fluorescent nanoparticles generated from an emergent class of materials we refer to as a Group of Uniform Materials Based on Organic Salts (GUMBOS). GUMBOS are largely frozen ionic liquids, although the concept is more general and is also easily applied to solid ionic materials with melting points in excess of 100 °C. Nanoparticles based on GUMBOS (nanoGUMBOS) derived from a NIR fluorophore are prepared using a reprecipitation method and evaluated for in vivo fluorescence imaging. Due to their uniformity, single-step preparation, and composite nature, nanoGUMBOS help to resolve issues with dye leakage problems innate to alternate cellular stains and unlock a myriad of applications for these materials, highlighting exciting possibilities for multifunctional nanoGUMBOS.
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