Humanized Mice for the Evaluation of Novel HIV-1 Therapies.
Humanized Mice for the Evaluation of Novel HIV-1 Therapies.
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DOI：
10.3389/fimmu.2021.636775
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发表时间：
2021
影响因子：
7.3
通讯作者：
Paust S
中科院分区：
文献类型：
--
作者：
Abeynaike S;Paust S
随着抗逆转录病毒疗法的发现，艾滋病毒-1感染已转变为一种可控的慢性病，需要终身治疗。然而，彻底根除该病毒仍然是我们无法实现的目标。这在一定程度上是因为病毒能够在组织储存库中保持休眠状态，对宿主的免疫系统“隐藏”。此外，HIV-1的高变异率导致了许多治疗方法的逃逸突变。无论如何，HIV-1新疗法的开发继续向前发展，从免疫疗法到基因编辑，都有一系列的方法。然而，为了评估体内发病机制以及治疗方法的有效性和安全性，合适的动物模型是必要的。为此，人性化鼠标于1988年由McCune开发，并在过去30年中不断改进。在这里，我们回顾了多年来所使用的各种人源化小鼠模型，并描述了它们在将HIV-1治疗策略转化到临床中的具体贡献。
With the discovery of antiretroviral therapy, HIV-1 infection has transitioned into a manageable but chronic illness, which requires lifelong treatment. Nevertheless, complete eradication of the virus has still eluded us. This is partly due to the virus’s ability to remain in a dormant state in tissue reservoirs, ‘hidden’ from the host’s immune system. Also, the high mutation rate of HIV-1 results in escape mutations in response to many therapeutics. Regardless, the development of novel cures for HIV-1 continues to move forward with a range of approaches from immunotherapy to gene editing. However, to evaluate in vivo pathogenesis and the efficacy and safety of therapeutic approaches, a suitable animal model is necessary. To this end, the humanized mouse was developed by McCune in 1988 and has continued to be improved on over the past 30 years. Here, we review the variety of humanized mouse models that have been utilized through the years and describe their specific contribution in translating HIV-1 cure strategies to the clinic.
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影响因子：
6.4
作者：
Biswas, Subhabrata;Chang, Hong;Marasco, Wayne A.
通讯作者：
Marasco, Wayne A.
DOI：
10.1084/jem.194.4.541
发表时间：
2001-08-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blazar BR;Lindberg FP;Ingulli E;Panoskaltsis-Mortari A;Oldenborg PA;Iizuka K;Yokoyama WM;Taylor PA
通讯作者：
Taylor PA
影响因子：
56.9
作者：
BARRESINOUSSI, F;CHERMANN, JC;MONTAGNIER, L
通讯作者：
MONTAGNIER, L
影响因子：
6.4
作者：
Billerbeck, Eva;Labitt, Rachael N.;Ploss, Alexander
通讯作者：
Ploss, Alexander
影响因子：
4.6
作者：
Baum, Marc M.;Ramirez, Christina M.;Gallay, Philippe A.
通讯作者：
Gallay, Philippe A.