Reduced tau expression in gastric cancer can identify candidates for successful Paclitaxel treatment.
Reduced tau expression in gastric cancer can identify candidates for successful Paclitaxel treatment.
复制标题
胃癌中 tau 表达的减少可以确定紫杉醇治疗成功的候选者。
DOI：
10.1038/sj.bjc.6603182
复制
发表时间：
2006-06-19
影响因子：
8.8
通讯作者：
Mori, M.
中科院分区：
文献类型：
--
作者：
Mimori, K.;Sadanaga, N.;Yoshikawa, Y.;Ishikawa, K.;Hashimoto, M.;Tanaka, F.;Sasaki, A.;Inoue, H.;Sugimachi, K.;Mori, M.
最近的一项研究表明，具有低“tau”表达的乳腺癌病例可以预测对紫杉醇给药的敏感性。在当前的研究中，通过确定给予Paclitaxel的候选者，确定了胃癌病例中tau表达的临床意义。对20例不能手术或未手术切除的胃癌组织标本进行了检查。在6次3小时静脉输注80 mg m−2 Paclitaxel后，通过计算机断层扫描转移病灶的大小评价Paclitaxel的临床有效性。通过免疫组织化学确定tau蛋白表达的状态。基于先前报道的分类方案，6例被分类为tau阴性表达（0，1+）病例，14例被分类为tau阳性表达（2+，3+）病例。所有六例（100%）tau阴性表达病例均对紫杉醇给药表现出有利的反应（部分反应或轻微反应）。然而，14例tau蛋白阳性表达的病例中有12例（86%）在紫杉醇给药后显示疾病进展（n=11）或无变化（n=1）。tau蛋白阴性表达的6例患者血清癌胚抗原值明显低于tau蛋白阳性表达的14例患者。这些数据表明，tau蛋白阴性表达可用于选择胃癌患者，这些患者将对紫杉醇治疗产生有利的反应。
A recent study disclosed that breast cancer cases with low ‘tau’ expression can predict susceptibility to Paclitaxel administration. In the current study, the clinical significance of tau expression in gastric cancer cases was established by identifying candidates with Paclitaxel administration. Tissue specimens from 20 cases of in-operable or noncuratively resected gastric cancer were examined. Subsequent to the administration of 80 mg m−2 of Paclitaxel in six 3-h intravenous infusions, the clinical effectiveness of Paclitaxel was evaluated by the size of metastatic lesions with computed tomography. The status of the tau expression was determined by immunohistochemistry. Based on a previously reported classification scheme, six were classified as tau-negative expression (0, 1+) cases and 14 were classified as tau-positive expression (2+, 3+) cases. All six (100%) cases of tau-negative expression showed a favourable response (partial response or minor response) to Paclitaxel administration. However, 12 (86%) of the 14 cases of tau-positive expression showed progressive disease (n=11) or no change (n=1) after Paclitaxel administration. The serum carcinoembryonic antigen values of the six cases of tau-negative expression were markedly decreased in comparison to the 14 tau-positive cases. These data indicate that tau-negative expression can be used to select gastric cancer patients, which will favourably respond to Paclitaxel treatment.
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DOI：
10.1083/jcb.101.4.1371
发表时间：
1985-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Binder LI;Frankfurter A;Rebhun LI
通讯作者：
Rebhun LI
影响因子：
5.7
作者：
Takahashi, T;Yamasaki, F;Ueno, NT
通讯作者：
Ueno, NT
影响因子：
8.4
作者：
Cascinu, S;Ficarelli, R;Cellerino, R
通讯作者：
Cellerino, R
影响因子：
45.3
作者：
Henderson, IC;Berry, DA;Norton, L
通讯作者：
Norton, L
DOI：
10.1073/pnas.0408974102
发表时间：
2005-06-07
影响因子：
11.1
作者：
Rouzier, R;Rajan, R;Pusztai, L
通讯作者：
Pusztai, L