A transcriptional profile of aging in the human kidney.
A transcriptional profile of aging in the human kidney.
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DOI：
10.1371/journal.pbio.0020427
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发表时间：
2004-12
期刊：
影响因子：
9.8
通讯作者：
Kim SK
中科院分区：
文献类型：
--
作者：
Rodwell GE;Sonu R;Zahn JM;Lund J;Wilhelmy J;Wang L;Xiao W;Mindrinos M;Crane E;Segal E;Myers BD;Brooks JD;Davis RW;Higgins J;Owen AB;Kim SK
在这项研究中，我们发现985个基因随着年龄的增长而改变肾皮质和髓质的表达。一些基因的转录随着年龄的增长而增加，这些基因在免疫细胞中特异性表达，这表明免疫监视或炎症随着年龄的增长而增加。年龄调节基因在皮质和髓质中显示出相似的衰老特征，表明衰老的共同潜在机制。这些年龄调节基因的表达谱不仅标志着年龄，而且还标志着老年人肾脏的相对健康和生理。最后，一组衰老调节的肾脏基因表明了可能在肾脏随年龄退化中发挥作用的特定机制和途径。一项对人类肾脏衰老的研究揭示了皮质和髓质中转录谱的相似变化，这表明一个共同的潜在衰老过程正在发生
In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age. A study of human aging in the kidney reveals similar changes in the transcriptional profile in cortex and medulla, suggesting that a common underlying aging process is taking place
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影响因子：
14.9
作者：
Zhong, S;Li, C;Wong, WH
通讯作者：
Wong, WH
影响因子：
4.6
作者：
Welle, S;Brooks, AI;Thornton, CA
通讯作者：
Thornton, CA
影响因子：
19.6
作者：
Hoang, K;Tan, JC;Myers, BD
通讯作者：
Myers, BD
DOI：
10.1073/pnas.012025199
发表时间：
2002-04-02
影响因子：
11.1
作者：
Su, AI;Cooke, MP;Hogenesch, JB
通讯作者：
Hogenesch, JB
影响因子：
30.8
作者：
Lee, CK;Weindruch, R;Prolla, TA
通讯作者：
Prolla, TA