Development, Diversity, and Neurogenic Capacity of Enteric Glia.
Development, Diversity, and Neurogenic Capacity of Enteric Glia.
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DOI：
10.3389/fcell.2021.775102
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发表时间：
2021
影响因子：
5.5
通讯作者：
Hao MM
中科院分区：
文献类型：
--
作者：
Boesmans W;Nash A;Tasnády KR;Yang W;Stamp LA;Hao MM
肠胶质细胞是一种令人着迷的细胞群。最初在肠壁中被确定为肠神经系统的“支持”细胞，过去20年的研究揭示了肠胶质细胞的大量功能。它们介导肠神经系统信号，并在肠道功能的局部调节中发挥重要作用。肠胶质细胞与其他胃肠道细胞类型（如上皮细胞和免疫系统细胞）相互作用以保持体内平衡，并对腔内含量敏感。它们在肠神经系统功能障碍和疾病相关条件下的反应性，反映了它们的功能多样性和表型异质性。肠胶质细胞具有可塑性，并与肠神经元的作用关系不断扩大，因此肠胶质细胞也具有神经源性。在这篇综述中，我们将重点介绍肠胶质细胞的发育及其在成人肠道异质性背后的机制。此外，我们还讨论了目前已知的肠胶质细胞在肠神经系统中作为神经前体的作用。
Enteric glia are a fascinating population of cells. Initially identified in the gut wall as the “support” cells of the enteric nervous system, studies over the past 20 years have unveiled a vast array of functions carried out by enteric glia. They mediate enteric nervous system signalling and play a vital role in the local regulation of gut functions. Enteric glial cells interact with other gastrointestinal cell types such as those of the epithelium and immune system to preserve homeostasis, and are perceptive to luminal content. Their functional versatility and phenotypic heterogeneity are mirrored by an extensive level of plasticity, illustrated by their reactivity in conditions associated with enteric nervous system dysfunction and disease. As one of the hallmarks of their plasticity and extending their operative relationship with enteric neurons, enteric glia also display neurogenic potential. In this review, we focus on the development of enteric glial cells, and the mechanisms behind their heterogeneity in the adult gut. In addition, we discuss what is currently known about the role of enteric glia as neural precursors in the enteric nervous system.
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影响因子：
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