Gene duplication and dosage effects during the early emergence of C4 photosynthesis in the grass genus Alloteropsis.
Gene duplication and dosage effects during the early emergence of C4 photosynthesis in the grass genus Alloteropsis.
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DOI：
10.1093/jxb/ery029
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发表时间：
2018-04-09
影响因子：
6.9
通讯作者：
Christin PA
中科院分区：
文献类型：
--
作者：
Bianconi ME;Dunning LT;Moreno-Villena JJ;Osborne CP;Christin PA
两个关键的C4基因的重复出现在一个C4循环的草属Alloteropsis是与转录丰度的增加基因重复进化多样化的重要性已主要讨论了遗传冗余允许neofunctionalization。在C4光合作用的情况下，它通过多种酶的协同选择来促进热带条件下的碳固定，遗传冗余的重要性并没有得到基因组研究的一致支持。在这里，我们测试了不同的作用，基因复制在早期进化的C4光合作用，通过剂量效应产生快速的步骤变化的表达水平。我们使用最近多样化为不同光合类型的草属别拟花属植物的全基因组数据，估计了基因拷贝数，并证明C4基因的两个重要家族中的重复与转录本丰度的增加沿着系统发育一致，在某些情况下通过纯粹的剂量效应。虽然在C4光合作用的最初出现过程中增加的基因拷贝数可能提供了一个快速的途径，以增强表达，我们也发现损失的重复收购后的基因编码更适合的异构体。因此，基因复制的剂量效应可能在C4生物化学的进化过程中作为一个短暂的过程，通过固定调节突变增加表达水平而变得过时。
Recurrent duplication of two key C4 genes during the emergence of a C4 cycle in the grass genus Alloteropsis is correlated with increases in transcript abundance The importance of gene duplication for evolutionary diversification has been mainly discussed in terms of genetic redundancy allowing neofunctionalization. In the case of C4 photosynthesis, which evolved via the co-option of multiple enzymes to boost carbon fixation in tropical conditions, the importance of genetic redundancy has not been consistently supported by genomic studies. Here, we test for a different role for gene duplication in the early evolution of C4 photosynthesis, via dosage effects creating rapid step changes in expression levels. Using genome-wide data for accessions of the grass genus Alloteropsis that recently diversified into different photosynthetic types, we estimate gene copy numbers and demonstrate that recurrent duplications in two important families of C4 genes coincided with increases in transcript abundance along the phylogeny, in some cases via a pure dosage effect. While increased gene copy number during the initial emergence of C4 photosynthesis probably offered a rapid route to enhanced expression, we also find losses of duplicates following the acquisition of genes encoding better-suited isoforms. The dosage effect of gene duplication might therefore act as a transient process during the evolution of a C4 biochemistry, rendered obsolete by the fixation of regulatory mutations increasing expression levels.
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影响因子：
12.3
作者：
Bellos E;Johnson MR;Coin LJ
通讯作者：
Coin LJ
影响因子：
30.8
作者：
Alkan, Can;Kidd, Jeffrey M.;Marques-Bonet, Tomas;Aksay, Gozde;Antonacci, Francesca;Hormozdiari, Fereydoun;Kitzman, Jacob O.;Baker, Carl;Malig, Maika;Mutlu, Onur;Sahinalp, S. Cenk;Gibbs, Richard A.;Eichler, Evan E.
通讯作者：
Eichler, Evan E.
DOI：
10.1073/pnas.0802432105
发表时间：
2008-09-02
影响因子：
11.1
作者：
Chen, Zuozhou;Cheng, C. -H. Christina;Chen, Liangbiao
通讯作者：
Chen, Liangbiao
DOI：
10.1111/evo.13250
发表时间：
2017-06
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Dunning LT;Lundgren MR;Moreno-Villena JJ;Namaganda M;Edwards EJ;Nosil P;Osborne CP;Christin PA
通讯作者：
Christin PA
影响因子：
9.2
作者：
Christin, Pascal-Antoine;Salamin, Nicolas;Besnard, Guillaume
通讯作者：
Besnard, Guillaume