Effects of Insulin on Vasoconstrictive Responses to Norepinephrine and Angiotensin II in Rabbit Femoral Artery and Vein
Effects of Insulin on Vasoconstrictive Responses to Norepinephrine and Angiotensin II in Rabbit Femoral Artery and Vein
复制标题
胰岛素对兔股动脉和静脉去甲肾上腺素和血管紧张素II血管收缩反应的影响
作者：
Shinji Yagi;S. Takata;Hiroaki Kiyokawa;M. Yamamoto;Y. Noto;T. Ikeda;N. Hattori
为了确定胰岛素是否对动脉和静脉具有血管扩张作用，在离体兔股动脉和静脉中研究了不同浓度的胰岛素（120 μU/ml、1.2 mU/ml、12 mU/ml 和 120 mU/ml）对去甲肾上腺素（NE）和血管紧张素 II（ANG II）引起的血管收缩的影响。将螺旋条悬浮在充满改良 Krebs 溶液（pH 7.4）的器官浴中，在 36°C 下用 95% O2/5% CO2 充气，并测量等渗收缩。胰岛素显着且剂量依赖性地抑制NE（动脉10−8 M，静脉10−7 M）诱导的血管收缩（动脉和静脉≥1.2 mU/ml）和ANG II（动脉3 × 10−10 M，静脉3 × 10−9 M）诱导的血管收缩（动脉≥1.2 mU/ml，≥12 mU/ml）。静脉的 mU/ml。结果表明，胰岛素对 NE 和 ANG II 诱导的动脉和静脉收缩具有抑制作用，这似乎是在接受胰岛素治疗的糖尿病患者中观察到的降压作用的一个促成因素。
To determine whether insulin has a vasodilator action on the artery and vein, the effects of insulin at varying concentrations (120 μU/ml, 1.2 mU/ml, 12 mU/ml, and 120 mU/ml) on vasoconstriction by norepinephrine (NE) and angiotensin II (ANG II) were studied in the isolated rabbit femoral artery and vein. Helical strips were suspended in an organ bath filled with modified Krebs solution (pH 7.4), were gassed with 95% O2/5% CO2 at 36°C, and isotonic contractions were measured. Insulin significantly and dose dependently inhibited the vasoconstriction induced by NE (10−8 M for the artery and 10−7 M for the vein) at ≥1.2 mU/ml for both the artery and vein and the vasoconstriction induced by ANG II (3 × 10−10 M for the artery and 3 × 10−9 M for the vein) at ≥1.2 mU/ml for the artery and ≥12 mU/ml for the vein. The results indicate that insulin has an inhibitory effect on NE- and ANG II–induced contraction in both the artery and vein, and this appeared to be a contributory factor in the hypotensive effect observed in diabetic patients treated with insulin.
胰岛素诱导大鼠骨骼肌快速超极化。
DOI：
10.1016/0005-2736(81)90098-5
发表时间：
1981
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Zierler,K;Rogus,EM
通讯作者：
Rogus,EM
胰岛素对青蛙骨骼肌纤维细胞内 pH 值的影响。
DOI：
10.1152/ajpcell.1985.248.3.c330
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Putnam,RW
通讯作者：
Putnam,RW