Activity in prelimbic cortex subserves fear memory reconsolidation over time.
Activity in prelimbic cortex subserves fear memory reconsolidation over time.
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DOI：
10.1101/lm.032631.113
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发表时间：
2013-12-16
期刊：
影响因子：
--
通讯作者：
Bertoglio LJ
中科院分区：
文献类型：
--
作者：
Stern CA;Gazarini L;Vanvossen AC;Hames MS;Bertoglio LJ
前边缘皮层与先前习得的恐惧的巩固有关。在此，我们报告了用GABAA激动剂蝇蕈醇（每半球0.2 μL中4.0 nmol）暂时灭活这个内侧前额叶皮层亚区能够在大鼠短暂提取后同样破坏1、7和21天的情景恐惧记忆。在所有情况下，当记忆重新激活被忽略时，这种效应被阻止。这些结果表明，最近和遥远的恐惧记忆是容易受到再巩固阻断前边缘皮层失活诱导。研究还表明，前边缘皮层失活对恐惧记忆的破坏作用持续超过11 d，并且没有显示出与预防相关的特征，如恢复。在短暂恢复/重新激活恐惧记忆后，将相同剂量和体积的蝇蕈醇双侧注入边缘下皮层并没有破坏它，正如在边缘前皮层失活的动物中所看到的那样。Zif 268/Egr 1的表达，立即早期基因的产物与记忆再巩固，也不太明显，在边缘下皮层比在边缘前皮层记忆检索/再激活。总而言之，目前的研究结果强调，前边缘皮层的活动可能会重新建立重新激活的厌恶记忆，因此，随着时间的推移，有助于他们的维护。
The prelimbic cortex has been implicated in the consolidation of previously learned fear. Herein, we report that temporarily inactivating this medial prefrontal cortex subregion with the GABAA agonist muscimol (4.0 nmol in 0.2 μL per hemisphere) was able to equally disrupt 1-, 7-, and 21-d-old contextual fear memories after their brief retrieval in rats. In all cases, this effect was prevented when memory reactivation was omitted. These results indicate that recent and remote fear memories are susceptible to reconsolidation blockade induced by prelimbic cortex inactivation. It was also demonstrated that the disrupting effect of prelimbic cortex inactivation on fear memory persisted over 11 d, and did not show extinction-related features, such as reinstatement. Infusing the same dose and volume of muscimol bilaterally into the infralimbic cortex after brief retrieval/reactivation of the fear memory did not disrupt it, as seen in prelimbic cortex-inactivated animals. The expression of Zif268/Egr1, the product of an immediate early gene related to memory reconsolidation, was also less pronounced in the infralimbic cortex than in prelimbic cortex following memory retrieval/reactivation. Altogether, the present findings highlight that activity in the prelimbic cortex may reestablish reactivated aversive memories and, therefore, contribute to their maintenance over time.
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影响因子：
2.6
作者：
Fani, Negar;Jovanovic, Tanja;Ely, Timothy D.;Bradley, Bekh;Gutman, David;Tone, Erin B.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
3.3
作者：
Alvares, L. De Oliveira;Genro, B. Pasqualini;Quillfeldt, J. A.
通讯作者：
Quillfeldt, J. A.
影响因子：
5.3
作者：
Klavir, Oded;Genud-Gabai, Rotem;Paz, Rony
通讯作者：
Paz, Rony
DOI：
10.1037/h0027676
发表时间：
1969-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BLANCHAR.RJ;BLANCHAR.DC
通讯作者：
BLANCHAR.DC
DOI：
10.1073/pnas.0909359107
发表时间：
2010-02-09
影响因子：
11.1
作者：
Choi, Dennis C.;Maguschak, Kimberly A.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.