Suppression of Insulin‐Induced Sympathetic Activation and Vasodilation by Dexamethasone in Humans
Suppression of Insulin‐Induced Sympathetic Activation and Vasodilation by Dexamethasone in Humans
复制标题
地塞米松抑制人类胰岛素诱导的交感神经激活和血管舒张
作者：
U. Scherrer;P. Vollenweider;D. Randin;E. Jéquier;P. Nicod;L. Tappy
背景瘦人类受试者的生理性高胰岛素血症会刺激交感神经活动和骨骼肌中的血流，但其潜在机制尚不清楚。潜在的机制包括胰岛素的中枢神经或外周作用。糖皮质激素可能会干扰这两种作用，从而减弱胰岛素在骨骼肌中的交感兴奋和血管舒张作用。方法和结果为了确定地塞米松是否减弱胰岛素诱导的交感神经激活和血管舒张，我们在短期服用这种药物之前和之后测量了正常血糖高胰岛素血症期间的肌肉交感神经活动和肌肉血流量。胰岛素浓度通常会使交感神经活动加倍并显着增加血流量，但短期服用地塞米松后没有这种刺激作用。相比之下，地塞米松不会改变对两种非胰岛素交感神经刺激、瓦尔萨尔瓦动作和将手浸入冰水中的反应，以及对小腿血管闭塞的血管舒张反应。结论这些结果表明，地塞米松对瘦健康人的胰岛素诱导的交感神经激活和血管舒张作用有显着损害。这项研究表明，对瘦受试者施用地塞米松可能提供一个实验模型来检查调节胰岛素的心血管、交感神经和代谢作用之间相互作用的潜在机制。
BackgroundPhysiological hyperinsulinemia in lean human subjects stimulates sympathetic nerve activity and blood flow in skeletal muscle, but the underlying mechanism is unknown. Potential mechanisms include central neural or peripheral actions of insulin. Glucocorticoids may potentially interfere with both such actions and thereby may attenuate sympathoexcitatory and vasodilatory effects of insulin in skeletal muscle. Methods and ResultsTo determine whether insulin-induced sympathetic activation and vasodilation are attenuated by dexamethasone, we measured muscle sympathetic nerve activity and muscle blood flow during euglycemic hyperinsulinemia before and after short-term administration of this pharmacological agent. Insulin concentrations, which normally doubled sympathetic activity and markedly increased blood flow, had no such stimulatory effect after short-term dexamethasone administration. In contrast, responses to two noninsulin sympathetic stimuli, the Valsalva maneuver and immersion of the hand in ice water, and the vasodilatory response to calf vascular occlusion were not altered by dexamethasone. ConclusionThese results demonstrate a dramatic impairment of insulin-induced sympathetic activation and vasodilation by dexamethasone in lean, healthy humans. This study suggests that dexamethasone administration to lean subjects may offer an experimental model to examine underlying mechanisms that regulate the interplay between cardiovascular, sympathetic, and metabolic effects of insulin.
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影响因子：
15.9
作者：
ANDERSON, EA;HOFFMAN, RP;MARK, AL
通讯作者：
MARK, AL
影响因子：
4.8
作者：
M. Schwartz;A. Sipols;J. L. Marks;G. Sanacora;Jeffery D. White;A. Scheurink;S. Kahn;D. Baskin;S. Woods;D. Figlewicz
通讯作者：
M. Schwartz;A. Sipols;J. L. Marks;G. Sanacora;Jeffery D. White;A. Scheurink;S. Kahn;D. Baskin;S. Woods;D. Figlewicz
ACTH-(4-10) 至 γ-MSH：一类新型中枢自主神经系统调节肽的证据。
DOI：
10.1152/ajpregu.1989.257.4.r681
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Gruber,KA;Callahan,MF
通讯作者：
Callahan,MF
影响因子：
20.3
作者：
M. Schwartz;D. Figlewicz;D. Baskin;S. Woods;D. Porte
通讯作者：
M. Schwartz;D. Figlewicz;D. Baskin;S. Woods;D. Porte
影响因子：
5.8
作者：
RIZZA, RA;MANDARINO, LJ;GERICH, JE
通讯作者：
GERICH, JE