Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats.
Effect of sequential treatments with alendronate, parathyroid hormone (1-34) and raloxifene on cortical bone mass and strength in ovariectomized rats.
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DOI：
10.1016/j.bone.2014.04.033
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发表时间：
2014-10
期刊：
影响因子：
4.1
通讯作者：
Lane, Nancy E.
中科院分区：
文献类型：
--
作者：
Amugongo, Sarah K.;Yao, Wei;Jia, Junjing;Dai, Weiwei;Lay, Yu-An E.;Jiang, Li;Harvey, Danielle;Zimmermann, Elizabeth A.;Schaible, Eric;Dave, Neil;Ritchie, Robert O.;Kimmel, Donald B.;Lane, Nancy E.
抗吸收和合成代谢药物经常连续或连续多年用于治疗骨质疏松症。然而，它们对皮质骨质量和骨强度的影响尚不清楚。对6月龄雌性大鼠进行假手术或卵巢切除（OVX）。OVX大鼠不治疗两个月，然后依次用载体（Veh）、hPTH（1-34）（PTH）、阿仑膦酸盐（Aln）或雷洛昔芬（Ral）治疗三个月，总共三个时期。在每个阶段后获得的尸检样本上测量胫骨中段皮质骨结构、质量、矿化和强度。在股骨近端尸检样本上测量骨压痕特性。大鼠雌激素缺乏8个月或更长时间导致皮质骨面积和厚度减少。PTH治疗3个月导致皮质内板层骨沉积，增加皮质骨面积、厚度和强度。当PTH停药而不进行后续治疗时，这些改善消失，但在最长测试时间内保持不变，Ral为6个月，Aln为3个月。抗吸收剂预处理在最终保留PTH处理下形成的额外皮质内板层骨方面也取得了一定的成功。这些处理不影响骨压痕特性。序贯治疗，涉及PTH和抗吸收剂，需要实现持久的改善皮质面积，厚度和强度在OVX大鼠。抗吸收治疗，无论是之前或之后的PTH，需要保留收益归因于一个合成代谢剂。
Anti-resorptive and anabolic agents are often prescribed for the treatment of osteoporosis continuously or sequentially for many years. However their impact on cortical bone quality and bone strength is not clear. Six-month old female rats were either sham operated or ovariectomized (OVX). OVX rats were left untreated for two months and then were treated with vehicle (Veh), hPTH (1-34) (PTH), alendronate (Aln), or raloxifene (Ral) sequentially for three month intervals, for a total of three periods. Mid-tibial cortical bone architecture, mass, mineralization, and strength were measured on necropsy samples obtained after each period. Bone indentation properties were measured on proximal femur necropsy samples. Eight or more months of estrogen deficiency in rats resulted in decreased cortical bone area and thickness. Treatment with PTH for 3 months caused the deposition of endocortical lamellar bone that increased cortical bone area, thickness, and strength. These improvements were lost when PTH was withdrawn without followup treatment, but were maintained for the maximum times tested, six months with Ral and three months with Aln. Pre-treatment with anti-resorptives was also somewhat successful in ultimately preserving the additional endocortical lamellar bone formed under PTH treatment. These treatments did not affect bone indentation properties. Sequential therapy that involved both PTH and anti-resorptive agents was required to achieve lasting improvements in cortical area, thickness, and strength in OVX rats. Anti-resorptive therapy, either prior to or following PTH, was required to preserve gains attributable to an anabolic agent.
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影响因子：
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