A coupled non-Fickian model of a cardiovascular drug delivery system.

A coupled non-Fickian model of a cardiovascular drug delivery system.
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心血管药物输送系统的耦合非菲克模型。

DOI:
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发表时间:
2016
期刊:
Mathematical medicine and biology : a journal of the IMA
影响因子:
--
通讯作者:
P. Oliveira
P. Oliveira
中科院分区:
--
文献类型:
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作者:
J. A. Ferreira;Jahed Naghipoor;P. Oliveira

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提出了一种使用可生物降解药物洗脱支架的心血管药物输送系统的耦合非菲克模型。数值结果是使用隐式-显式有限元方法获得的。分析了血管刚度对支架洗脱​​药物转运的影响。本文提出的结果提出了使药物输送曲线适应患者需求的新视角。
A coupled non-Fickian model of a cardiovascular drug delivery system using a biodegradable drug-eluting stent is proposed. The numerical results are obtained using an implicit-explicit finite-element method. The influence of vessel stiffness on the transport of drug eluted from the stent is analysed. The results presented in this paper suggest new perspectives to adapt the drug delivery profile to the needs of the patient.
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