Arterial stiffness identification of the human carotid artery using the stress-strain relationship in vivo.
Arterial stiffness identification of the human carotid artery using the stress-strain relationship in vivo.
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DOI：
10.1016/j.ultras.2011.09.006
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发表时间：
2012-03
期刊：
影响因子：
4.2
通讯作者：
Konofagou, E. E.
中科院分区：
文献类型：
--
作者：
Khamdaeng, T.;Luo, J.;Vappou, J.;Terdtoon, P.;Konofagou, E. E.
动脉僵硬度被公认为动脉疾病的可靠指标。颈动脉硬度的增加与颈动脉疾病相关，例如，动脉粥样硬化斑块、血栓形成、狭窄等。已经提出了几种用于颈动脉硬度评估的方法。在这项研究中，使用压平眼压计和基于超声的运动估计技术的体内无创评估应用于7名健康志愿者（年龄28 ± 3.6岁），以分别确定左颈总动脉（CCA）的压力和壁位移。颈动脉压是通过假设平均血压和舒张压在整个动脉树中保持恒定而使用校准方法获得的。使用1D互相关技术对以505-1010 Hz的帧速率采集的超声射频（RF）信号估计局部颈动脉壁位移。杨氏模量在两种不同的假设下进行估计：（i）线弹性双平行弹簧模型和（ii）二维非线性超弹性模型。然后在人体体内建立周向应力（σθ）和应变（εθ）关系。观察到周向应力-应变曲线的斜率变化，并将其定义为过渡点。分别用第一种方法和第二种方法测定弹性膜（E1）、弹性蛋白-胶原纤维（E2）和胶原纤维（E3）的杨氏模量以及转变点之前（）和之后（）的增量杨氏模量，以描述不同动脉壁成分的复杂机械相互作用的贡献。7名健康志愿者的平均E_1、E_2和E_3分别为0.15 ± 0.04、0.89 ± 0.27和0.75 ± 0.29MPa。发现完整壁（外膜和图尼卡膜层）的平均和分别等于0.16 ± 0.04 MPa和0.90 ± 0.25 MPa。发现外膜图尼卡的平均和分别等于0.18 ± 0.05 MPa和0.84 ± 0.22 MPa。发现图尼卡中膜的平均和分别等于0.19 ± 0.05 MPa和0.90 ± 0.25 MPa。在心动周期的收缩期，颈动脉的刚度随应变而增加。总之，无创测量正常人颈动脉局部应力-应变关系和刚度的可行性在人体体内得到了证实。
Arterial stiffness is well accepted as a reliable indicator of arterial disease. Increase in carotid arterial stiffness has been associated with carotid arterial disease, e.g., atherosclerotic plaque, thrombosis, stenosis, etc. Several methods for carotid arterial stiffness assessments have been proposed. In this study, in-vivo noninvasive assessment using applanation tonometry and an ultrasound-based motion estimation technique was applied in seven healthy volunteers (age 28 ± 3.6 years old) to determine pressure and wall displacement in the left common carotid artery (CCA), respectively. The carotid pressure was obtained using a calibration method by assuming that the mean and diastolic blood pressures remained constant throughout the arterial tree. The regional carotid arterial wall displacement was estimated using a 1D cross-correlation technique on the ultrasound radio frequency (RF) signals acquired at a frame rate of 505–1010 Hz. Young’s moduli were estimated under two different assumptions: (i) a linear elastic two-parallel spring model and (ii) a two-dimensional, nonlinear, hyperelastic model. The circumferential stress (σθ) and strain (εθ) relationship was then established in humans in vivo. A slope change in the circumferential stress-strain curve was observed and defined as a transition point. The Young’s moduli of the elastic lamellae (E1), elastin-collagen fibers (E2) and collagen fibers (E3) and the incremental Young’s moduli before () and after the transition point () were determined from the first and second approach, respectively, to describe the contribution of the complex mechanical interaction of the different arterial wall constituents. The average E1, E2 and E3 from seven healthy volunteers were found to be equal to 0.15 ± 0.04, 0.89 ± 0.27 and 0.75 ± 0.29 MPa, respectively. The average and of the intact wall (both the tunica adventitia and tunica media layers) were found to be equal to 0.16 ± 0.04 MPa and 0.90 ± 0.25 MPa, respectively. The average and of the tunica adventitia were found to be equal to 0.18 ± 0.05 MPa and 0.84 ± 0.22 MPa, respectively. The average and of the tunica media were found to be equal to 0.19 ± 0.05 MPa and 0.90 ± 0.25 MPa, respectively. The stiffness of the carotid artery increased with strain during the systolic phase of cardiac cycle. In conclusion, the feasibility of measuring the regional stress-strain relationship and stiffness of the normal human carotid artery noninvasively was demonstrated in human in vivo.
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影响因子：
2.9
作者：
Arnett, DK;Chambless, LE;Riley, W
通讯作者：
Riley, W
影响因子：
5.3
作者：
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COX, RH
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COX, RH
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Holzapfel, GA;Gasser, TC;Ogden, RW
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影响因子：
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作者：
Reference Values for Arterial Stiffness' Collaboration
通讯作者：
Reference Values for Arterial Stiffness' Collaboration