Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients.
Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients.
复制标题
DOI：
10.3389/fpain.2023.1117842
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
偏头痛是世界卫生组织公认的一种主要头痛疾病，是影响全球残疾的最鲜为人知、最令人衰弱的神经疾病之一。慢性疼痛障碍在顺性别女性中比男性更容易被诊断出来，这表明女性的性激素可能是包括偏头痛在内的慢性疼痛的媒介，和/或雄激素可以起到保护作用。本文讨论了主要的性激素、雌激素、孕酮和睾酮在偏头痛病理生理学中的作用的分子机制。此外，还介绍了目前文献中描述的少量性激素在偏头痛中的作用，包括催乳素、黄体生成素、卵泡刺激素和促性腺激素释放激素。由于变性人和性别不一致(Trans*)患者是一个服务不足的患者群体，其中性别肯定的性激素替代疗法(HRT)在医学上通常是必要的，以使生物性别与性别认同相一致，因此我们将在这些主要和次要的性激素对跨*患者偏头痛的发生和管理的背景下讨论顺性患者群体的结果。
Migraine is a primary headache disorder recognized by the World Health Organization as one of the most poorly understood and debilitating neurological conditions impacting global disability. Chronic pain disorders are more frequently diagnosed among cisgender women than men, suggesting that female sex hormones could be responsible for mediating chronic pain, including migraine and/or that androgens can be protective. This review discusses the major gonadal hormones, estrogens, progesterone, and testosterone in the context of molecular mechanisms by which they play a role in migraine pathophysiology. In addition, the literature to date describing roles of minor sex hormones including prolactin, luteinizing hormone, follicular stimulating hormone, and gonadotropin releasing hormone in migraine are presented. Because transgender and gender non-conforming (trans*) individuals are an underserved patient population in which gender-affirming sex hormone replacement therapy (HRT) is often medically necessary to align biological sex with gender identity, results from cisgender patient populations are discussed in the context of these major and minor sex hormones on migraine incidence and management in trans* patients.
登录
查看更多内容
DOI：
10.1186/1129-2377-14-62
发表时间：
2013-07-23
期刊：
The journal of headache and pain
影响因子：
--
作者：
Costa C;Tozzi A;Rainero I;Cupini LM;Calabresi P;Ayata C;Sarchielli P
通讯作者：
Sarchielli P
影响因子：
2
作者：
Cetinkaya, Ayhan;Kilinc, Erkan;Ogun, Muhammed Nur
通讯作者：
Ogun, Muhammed Nur
DOI：
10.1007/s10072-020-04643-8
发表时间：
2020-12
期刊：
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
影响因子：
--
作者：
Allais G;Chiarle G;Sinigaglia S;Airola G;Schiapparelli P;Benedetto C
通讯作者：
Benedetto C
影响因子：
4.8
作者：
COLOMBO, JA;SAWYER, CH
通讯作者：
SAWYER, CH
影响因子：
9.9
作者：
Cernuda-Morollon, Eva;Larrosa, Davinia;Pascual, Julio
通讯作者：
Pascual, Julio