Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss.
Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss.
复制标题
噪声引起的听力损失的内在机制和药理处理。
作者：
Xu K;Xu B;Gu J;Wang X;Yu D;Chen Y
噪音占全球听力损失的三分之一。令人遗憾的是，噪声性听力损失（NIHL）由于其难以捉摸的致病机制尚未完全阐明，被认为是不可逆的。遗传和环境因素之间复杂的相互作用，影响许多下游分子和细胞事件，有助于NIHL的发生。在临床环境中，除了类固醇之外没有有效的治疗药物，这是NIHL患者的唯一治疗选择。因此，对NIHL治疗的需求目前尚未得到满足，随着我们对其潜在调控机制的理解的最新进展，导致了许多新的文献关注这一治疗领域。改变内耳局部药物输送的新技术的出现导致了有希望的治疗方法的发展，这些方法目前正在临床研究中。本文综述了NIHL的基本原理和潜在的治疗方法，以及生物材料和纳米药物在内耳给药中的应用。本综述的目的是为NIHL的基础研究和未来的临床转化提供激励。
Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that have not been fully elucidated. The complex interaction between genetic and environmental factors, which influences numerous downstream molecular and cellular events, contributes to the NIHL. In clinical settings, there are no effective therapeutic drugs other than steroids, which are the only treatment option for patients with NIHL. Therefore, the need for treatment of NIHL that is currently unmet, along with recent progress in our understanding of the underlying regulatory mechanisms, has led to a lot of new literatures focusing on this therapeutic field. The emergence of novel technologies that modify local drug delivery to the inner ear has led to the development of promising therapeutic approaches, which are currently under clinical investigation. In this comprehensive review, we focus on outlining and analyzing the basics and potential therapeutics of NIHL, as well as the application of biomaterials and nanomedicines in inner ear drug delivery. The objective of this review is to provide an incentive for NIHL's fundamental research and future clinical translation.
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