Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking.
Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking.
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DOI：
10.3389/fchem.2014.00105
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发表时间：
2014
影响因子：
5.5
通讯作者：
Barata TS
中科院分区：
文献类型：
--
作者：
Conniot J;Silva JM;Fernandes JG;Silva LC;Gaspar R;Brocchini S;Florindo HF;Barata TS
癌症是折磨全球人民的最常见疾病之一。由于癌症作为一种疾病的复杂性，需要新的治疗方法。目前的许多治疗方法毒性很大，充其量也只有有限的疗效。对肿瘤生物学和免疫学的进一步了解使得开发出毒性最小的特异性免疫疗法成为可能。强调单克隆抗体、免疫佐剂、疫苗和细胞治疗的性能是很重要的。尽管这些方法显示出不同程度的临床疗效，但它们表明了开发新策略的潜力。靶向免疫治疗正在探索克服恶性肿瘤细胞的异质性和肿瘤及其微环境诱导的免疫抑制。纳米递送策略寻求最大限度地减少对恶性组织和细胞的系统性暴露于靶向治疗。细胞内渗透已通过使用功能化颗粒进行了检查。正在开发这些与纳米颗粒相关的药物，用于成像、诊断和癌症靶向治疗。尽管纳米颗粒本质上是复杂的药物，但至少在原则上，赋予不同类型功能的能力允许合理考虑这些纳米递送策略可以用于组合药物。靶向纳米递送系统的发展，其中治疗和显像剂合并到一个单一的平台是一个有吸引力的策略。目前，一些基于纳米平台的配方，如聚合纳米颗粒、胶束、脂质体和树状大分子，正处于临床前和临床开发阶段。本文将介绍目前研究的用于癌症免疫治疗的纳米递送策略、癌症靶向机制和纳米载体功能化方法。我们还打算讨论适合用作成像技术和癌症治疗选择的新兴纳米基方法。
Cancer is one of the most common diseases afflicting people globally. New therapeutic approaches are needed due to the complexity of cancer as a disease. Many current treatments are very toxic and have modest efficacy at best. Increased understanding of tumor biology and immunology has allowed the development of specific immunotherapies with minimal toxicity. It is important to highlight the performance of monoclonal antibodies, immune adjuvants, vaccines and cell-based treatments. Although these approaches have shown varying degrees of clinical efficacy, they illustrate the potential to develop new strategies. Targeted immunotherapy is being explored to overcome the heterogeneity of malignant cells and the immune suppression induced by both the tumor and its microenvironment. Nanodelivery strategies seek to minimize systemic exposure to target therapy to malignant tissue and cells. Intracellular penetration has been examined through the use of functionalized particulates. These nano-particulate associated medicines are being developed for use in imaging, diagnostics and cancer targeting. Although nano-particulates are inherently complex medicines, the ability to confer, at least in principle, different types of functionality allows for the plausible consideration these nanodelivery strategies can be exploited for use as combination medicines. The development of targeted nanodelivery systems in which therapeutic and imaging agents are merged into a single platform is an attractive strategy. Currently, several nanoplatform-based formulations, such as polymeric nanoparticles, micelles, liposomes and dendrimers are in preclinical and clinical stages of development. Herein, nanodelivery strategies presently investigated for cancer immunotherapy, cancer targeting mechanisms and nanocarrier functionalization methods will be described. We also intend to discuss the emerging nano-based approaches suitable to be used as imaging techniques and as cancer treatment options.
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影响因子：
4.9
作者：
Alexis F;Pridgen E;Molnar LK;Farokhzad OC
通讯作者：
Farokhzad OC
DOI：
10.3181/0808-mr-250
发表时间：
2009-02
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Blanco E;Kessinger CW;Sumer BD;Gao J
通讯作者：
Gao J
影响因子：
7.2
作者：
Bos R;Marquardt KL;Cheung J;Sherman LA
通讯作者：
Sherman LA
影响因子：
20.3
作者：
Agemy, Lilach;Sugahara, Kazuki N.;Ruoslahti, Erkki
通讯作者：
Ruoslahti, Erkki
影响因子：
46.9
作者：
Ahrens, ET;Flores, R;Morel, PA
通讯作者：
Morel, PA