T follicular helper cells and antibody response to Hepatitis B virus vaccine in HIV-1 infected children receiving ART.
T follicular helper cells and antibody response to Hepatitis B virus vaccine in HIV-1 infected children receiving ART.
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T卵泡辅助细胞和对HIV-1感染儿童接受ART的对丙型肝炎病毒疫苗的抗体反应。
DOI：
10.1038/s41598-017-09165-6
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发表时间：
2017-08-21
影响因子：
4.6
通讯作者：
Chiodi F
中科院分区：
文献类型：
--
作者：
Bekele Y;Yibeltal D;Bobosha K;Andargie TE;Lemma M;Gebre M;Mekonnen E;Habtewold A;Nilsson A;Aseffa A;Howe R;Chiodi F
乙型肝炎病毒疫苗在儿童中预防乙型肝炎病毒感染和相关癌症的有效率为95%。我们在接受抗逆转录病毒治疗的HIV-1感染儿童（n = 49）和对照组（n = 63）中进行了一项前瞻性研究，以评估三剂HBV疫苗在间隔4周的加速计划下的体液和细胞反应。接种后1个月，除4名HIV-1感染儿童外，所有儿童对HBV疫苗均显示保护性抗体（ab）滴度；感染儿童的抗体滴度较低（P < 0.0001）。6个月时，HIV-1感染儿童和对照组的Ab滴度均下降（P < 0.0001）。接种疫苗前，对照组的循环Tfh （cTFh）细胞频率为20.3%，感染儿童的循环cTFh细胞频率为20.8%，接种疫苗后保持相似。在基线和接种疫苗后1个月，两组cTfh细胞在HBV抗原活化后的细胞因子表达具有可比性。感染儿童血浆CXCL13水平升高（P < 0.0001），与基线时cTfh细胞频率相关。总之，HIV-1感染儿童对HBV疫苗的抗体应答较低。在感染儿童和对照组中，cTfh细胞的频率和激活谱是相似的，这表明除Tfh细胞外的其他细胞对HBV疫苗的抗体反应受损负有责任。
HBV vaccine has 95% efficacy in children to prevent HBV infection and related cancer. We conducted a prospective study in HIV-1 infected children receiving ART (n = 49) and controls (n = 63) to assess humoral and cellular responses to HBV vaccine provided with three doses under an accelerated schedule of 4 weeks apart. At 1 month post-vaccination all children, except 4 HIV-1 infected, displayed protective antibody (ab) titers to HBV vaccine; ab titers were lower in infected children (P < 0.0001). Ab titers decreased (P < 0.0001) in both HIV-1 infected and control children at 6 months. The frequency of circulating Tfh (cTFh) cells was 20.3% for controls and 20.8% for infected children prior to vaccination and remained comparable post-vaccination. Cytokine expression by cTfh cells upon activation with HBV antigen was comparable in the two groups at baseline and 1 month post-vaccination. Higher plasma levels (P < 0.0001) of CXCL13 were found in infected children which correlated with cTfh cell frequency at baseline. In conclusion, a lower ab response to HBV vaccine was measured in HIV-1 infected children. The frequency and activation profile of cTfh cells was comparable in infected children and controls suggesting that cells other than Tfh cells are responsible for impaired ab response to HBV vaccine.
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DOI：
10.4049/jimmunol.1401225
发表时间：
2015-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fairfax KC;Everts B;Amiel E;Smith AM;Schramm G;Haas H;Randolph GJ;Taylor JJ;Pearce EJ
通讯作者：
Pearce EJ
影响因子：
1.6
作者：
Bekele, Yonas;Amu, Sylvie;Chiodi, Francesca
通讯作者：
Chiodi, Francesca
影响因子：
5.5
作者：
Costumbrado, John;Stirland, Ali;Malek, Mark
通讯作者：
Malek, Mark
影响因子：
2.4
作者：
Franco, Elisabetta;Bagnato, Barbara;Zaratti, Laura
通讯作者：
Zaratti, Laura
影响因子：
3.7
作者：
Jin, Hui;Tan, Zhaoying;Liu, Pei
通讯作者：
Liu, Pei