New and old roles of plasmodesmata in immunity and parallels to tunneling nanotubes.
New and old roles of plasmodesmata in immunity and parallels to tunneling nanotubes.
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DOI：
10.1016/j.plantsci.2014.01.006
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发表时间：
2014-05
期刊：
影响因子：
5.2
通讯作者：
Lee, Jung-Youn
中科院分区：
文献类型：
--
作者：
Lee, Jung-Youn
有效的细胞间通讯对单细胞和多细胞生物的生存都至关重要。在多细胞植物中，跨越细胞壁边界的直接细胞偶联是通过长膜细胞质桥，即胞间连丝介导的。最近令人兴奋的发现表明，这种膜层细胞间通道的出现并不是植物谱系所独有的，而是比以前认为的在生物王国中更为普遍。这些通道之间存在着惊人的功能相似性，因为它们都促进了各种形式的大分子的交换，但同时也允许一些机会性病原体利用这些桥梁从一个宿主细胞转移到另一个宿主细胞。然而，宿主免疫监视系统也可能进化出一些策略来抵消病原体对关键细胞基础设施的利用。事实上，一个新兴的新范式表明，通过胞间连丝的细胞连接在先天免疫反应中起着重要作用。通过对植物将胞间连丝整合到免疫信号通路中的关键分子的分析，提出了植物将胞间连丝整合到免疫信号通路的调控机制的初步假设。
Effective cell-to-cell communication is critical for the survival of both unicellular and multicellular organisms. In multicellular plants, direct cell coupling across the cell wall boundaries is mediated by long membrane-lined cytoplasmic bridges, the plasmodesmata. Exciting recent discoveries suggest that the occurrence of such membrane-lined intercellular channels is not unique to plant lineages but more prevalent across biological kingdoms than previously assumed. Striking functional analogies exist among those channels since they all facilitate the exchange of various forms of macromolecules, but at the same time allow some opportunistic pathogens to exploit those bridges to move from one host cell to another. However, host immune surveillance system may have also evolved strategies to offset such exploitation of the critical cellular infrastructure by the pathogen. Indeed, an emerging new paradigm illustrates that cellular connectivity via plasmodesmata plays an important role in innate immune responses. Preliminary hypothesis is proposed as to how the regulatory mechanism evolved by which plants integrated plasmodesmata into immune signaling pathways based on the key players identified in this process.
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