Development of Inspired Therapeutics Pediatric VAD: Benchtop Evaluation of Impeller Performance and Torques for MagLev Motor Design.
Development of Inspired Therapeutics Pediatric VAD: Benchtop Evaluation of Impeller Performance and Torques for MagLev Motor Design.
复制标题
DOI：
10.1007/s13239-021-00578-z
复制
发表时间：
2022-04
影响因子：
1.8
通讯作者：
Dasse KA
中科院分区：
文献类型：
--
作者：
Tompkins LH;Prina SR;Gellman BN;Morello GF;Roussel T;Kopechek JA;Williams SJ;Petit PC;Slaughter MS;Koenig SC;Dasse KA
尽管第一代体外机械循环支持（MCS）系统在世界各地广泛使用，但仍需要下一代更小、更便携的设备（设计为无电缆和最少数量的连接器），可用于所有住院和运输环境，以支持心力衰竭患者。此外，需要一种可普遍用于所有使用适应症的系统，包括适用于成人、新生儿和儿科患者的心肺转流（CPB）、单心室或双心室支持（VAD）、体外膜氧合（ECMO）和呼吸辅助。提供一个单一的，设计良好的，通用的技术可以减少人为错误的发生率，通过限制医院工作人员在一个单一的系统上的各种适应症的培训需求，而不是必须在多个复杂的系统上进行培训。本手稿的目的是描述开发首个原型泵的初步研究，该泵用作采用Inspired Universal MCS技术的儿科患者的心室辅助器械。Inspired VAD Universal系统是一种创新的体外血液泵送系统，在单个便携式集成电机/控制器单元中采用了新型MagLev技术，可为各种不同的一次性泵模块供电，用于新生儿、儿科和成人心室和呼吸辅助。构建了Inspired Pediatric VAD原型，以确定儿科应用的血流动力学要求。量化了内叶轮的液压扭矩的大小/范围。使用含有加热血液模拟溶液的静态模拟流动回路模型对原型泵的流体动力学性能进行基准测试，以在转速（500 - 6000 RPM）、流速（0 - 3.5 L/min）和压力（0至~420 mmHg）范围内测试泵。该装置最初由轴驱动的直流电动机驱动，而不是完全的MagLev设计，该设计也用于计算作用在叶轮上的流体扭矩。儿科VAD在6000 RPM时产生的流量高达4.27 L/min，压力为127 mmHg，产生的压力和流量值均在预期设计规范范围内。根据经验确定的性能和扭矩值确定了用于Inspired Universal MagLev系统的磁悬浮电机设计的要求。我们研发的下一步是制造一个完全集成的功能性磁悬浮泵、电机和控制器系统，该系统符合产品要求规范，并达到急性绵羊动物研究的准备状态，以验证系统的安全性和性能。
Despite the availability of first-generation extracorporeal mechanical circulatory support (MCS) systems that are widely used throughout the world, there is a need for the next generation of smaller, more portable devices (designed without cables and a minimal number of connectors) that can be used in all in-hospital and transport settings to support patients in heart failure. Moreover, a system that can be universally used for all indications for use including cardiopulmonary bypass (CPB), uni- or biventricular support (VAD), extracorporeal membrane oxygenation (ECMO) and respiratory assist that is suitable for use for adult, neonate, and pediatric patients is desirable. Providing a single, well designed, universal technology could reduce the incidence of human errors by limiting the need for training of hospital staff on a single system for a variety of indications throughout the hospital rather than having to train on multiple complex systems. The objective of this manuscript is to describe preliminary research to develop the first prototype pump for use as a ventricular assist device for pediatric patients with the Inspired Universal MCS technology. The Inspired VAD Universal System is an innovative extracorporeal blood pumping system utilizing novel MagLev technology in a single portable integrated motor/controller unit which can power a variety of different disposable pump modules intended for neonate, pediatric, and adult ventricular and respiratory assistance. A prototype of the Inspired Pediatric VAD was constructed to determine the hemodynamic requirements for pediatric applications. The magnitude/range of hydraulic torque of the internal impeller was quantified. The hydrodynamic performance of the prototype pump was benchmarked using a static mock flow loop model containing a heated blood analogue solution to test the pump over a range of rotational speeds (500 - 6000 RPM), flow rates (0 - 3.5 L/min), and pressures (0 to ~420 mmHg). The device was initially powered by a shaft-driven DC motor in lieu of a full MagLev design, which was also used to calculate the fluid torque acting on the impeller. The pediatric VAD produced flows as high as 4.27 L/min against a pressure of 127 mmHg at 6000 RPM and the generated pressure and flow values fell within the desired design specifications. The empirically determined performance and torque values establish the requirements for the magnetically levitated motor design to be used in the Inspired Universal MagLev System. This next step in our research and development is to fabricate a fully integrated and functional magnetically levitated pump, motor and controller system that meets the product requirement specifications and achieves a state of readiness for acute ovine animal studies to verify safety and performance of the system.
登录
查看更多内容
DOI：
10.5090/kjtcs.2013.46.6.391
发表时间：
2013-12
期刊：
The Korean journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Wilmot I;Lorts A;Morales D
通讯作者：
Morales D
DOI：
10.1016/b978-0-12-810491-0.00011-4
发表时间：
2018-01-01
期刊：
MECHANICAL CIRCULATORY AND RESPIRATORY SUPPORT
影响因子：
--
作者：
Masuzawa, Toru;Osa, Masahiro;Mapley, Martin
通讯作者：
Mapley, Martin
影响因子：
37.8
作者：
Almond, Christopher S. D.;Thiagarajan, Ravi R.;Singh, T. P.
通讯作者：
Singh, T. P.
影响因子：
2.4
作者：
Hijikata, Wataru;Shinshi, Tadahiko;Shimokohbe, Akira
通讯作者：
Shimokohbe, Akira
影响因子：
2.4
作者：
Boes, Stefan;Ochsner, Gregor;Daners, Marianne Schmid
通讯作者：
Daners, Marianne Schmid