Recent advancements in multimodality treatment of gliomas.

Recent advancements in multimodality treatment of gliomas.
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DOI:
10.2217/fon.11.102
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发表时间:
2011-10
期刊:
Future oncology (London, England)
影响因子:
--
通讯作者:
Chakravarti A
Chakravarti A
中科院分区:
其他
文献类型:
--
作者:
Hadziahmetovic M;Shirai K;Chakravarti A

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胶质瘤占恶性成人脑肿瘤的绝大多数。尽管已经做出了巨大的努力来优化高级别胶质瘤患者的治疗,但预后仍然很差,特别是对于胶质母细胞瘤患者。由这些肿瘤赋予的令人沮丧的预后部分是由扩散浸润到邻近脑组织的倾向引起的,但也是由这些肿瘤对化疗和放疗的固有抗性引起的。本文回顾了胶质瘤患者(包括原发性和复发性)多方式治疗的最新进展,重点是新兴的靶向治疗。此外,外照射放射治疗的选择,包括调强放射治疗和粒子(质子和碳离子)放射治疗进行了审查。
Gliomas account for the vast majority of malignant adult brain tumors. Even though tremendous effort has been made to optimize treatment of patients with high-grade glioma, the prognosis remains poor, especially for patients with glioblastoma. The dismal prognosis conferred by these tumors is in part caused by the tendency to diffusely infiltrate into neighboring brain tissue, but also by the inherent resistance of these tumors to both chemotherapy and radiation. This article reviews the recent advancements in multimodality treatment of patients with gliomas, both in the primary and recurrent setting, with an emphasis on the emerging targeted therapies. Moreover, the external beam radiotherapy options, including intensity modulated radiotherapy and particle (proton and carbon ion) radiotherapy are reviewed.
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