Chemistries and applications of DNA-natural product conjugate.
Chemistries and applications of DNA-natural product conjugate.
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DNA-天然产物缀合物的化学和应用
DOI：
10.3389/fchem.2022.984916
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
天然产物及其衍生物在化疗方面做出了巨大贡献，特别是在治疗肿瘤和感染方面。尽管取得了这些成就，但以天然产物为基础的小分子药物通常存在副作用、流通时间短和溶解度问题。为了克服这些缺点，一种常见的方法是将另一种生物功能基序整合到天然产品化合物中，从而实现靶向或协同治疗。最有希望的策略之一是形成DNA-天然产物结合物，以改善治疗目的。被掺入的DNA分子可以作为适体，即抗体的基于核酸的同系物，与感兴趣的疾病靶点特异性结合，或者作为基因治疗剂，如免疫佐剂或反义，以实现协同化疗-基因治疗。DNA-天然产物结合物也可以被结合到其他DNA纳米结构中，以改善药物的给药和给药。这篇简短的综述旨在为化学界提供关于DNA-天然产物结合物这一新兴主题的简要概述，用于高级疗法。本文重点介绍了结合物的基本概念、常用的结合物化学方法，以及DNA-天然产物结合物在靶向治疗和协同治疗中的应用。讨论和观点一节也讨论了这一领域的未来前景和挑战。
Natural products and their derivatives have made great contributions to chemotherapy, especially for the treatment of tumors and infections. Despite the achievements, natural product-based small molecule drugs usually suffer from side effects, short circulation time, and solubility issue. To overcome these drawbacks, a common approach is to integrate another bio-functional motif into a natural product compound, enabling targeted or synergistic therapy. One of the most promising strategies is to form a DNA-natural product conjugate to improve therapeutic purposes. The incorporated DNA molecules can serve as an aptamer, a nucleic-acid-based congener of antibody, to specifically bind to the disease target of interest, or function as a gene therapy agent, such as immuno-adjuvant or antisense, to enable synergistic chemo-gene therapy. DNA-natural product conjugate can also be incorporated into other DNA nanostructures to improve the administration and delivery of drugs. This minireview aims to provide the chemistry community with a brief overview on this emerging topic of DNA-natural product conjugates for advanced therapeutics. The basic concepts to use the conjugation, the commonly used robust conjugation chemistries, as well as applications in targeted therapy and synergistic therapy of using DNA-natural product conjugates, are highlighted in this minireview. Future perspectives and challenges of this field are also discussed in the discussion and perspective section.
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