Investigating Epidemiologic and Molecular Links Between Patients With Community- and Hospital-Acquired Influenza A: 2017-2018 and 2019-2020, Michigan.
Investigating Epidemiologic and Molecular Links Between Patients With Community- and Hospital-Acquired Influenza A: 2017-2018 and 2019-2020, Michigan.
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DOI：
10.1093/ofid/ofad061
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发表时间：
2023-02
影响因子：
4.2
通讯作者：
Petrie, Joshua G.
中科院分区：
文献类型：
--
作者：
Wan, Tiffany;Lauring, Adam S.;Valesano, Andrew L.;Fitzsimmons, William J.;Bendall, Emily E.;Kaye, Keith S.;Petrie, Joshua G.
医院获得性流感病毒感染（HAII）可导致严重的发病率和死亡率。确定潜在的传播途径可以为预防战略提供信息。我们确定了2017-2018年和2019-2020年流感季节期间在一家大型三级医院检测出甲型流感病毒阳性的所有住院患者。从电子病历中检索入院日期、住院服务地点和临床流感检测信息。定义了流行病学相关流感患者的时间-地点组，包含≥1例假定HAII病例（首次阳性≥入院后48小时）。 通过全基因组测序评估时间-位置组内的遗传相关性。在2017-2018年流感季期间，230名患者对甲型流感（H3 N2）或未亚型甲型流感检测呈阳性，其中包括26名HAII。在2019-2020年流感季期间，共发现159例甲型H1N1流感pdm 09或未分型甲型流感阳性患者，包括33例甲型H1N1流感患者。在2017-2018年和2019-2020年，分别获得了177例（77%）和57例（36%）甲型流感病例的共有序列。在所有甲型流感病例中，2017-2018年确定了10个时间-地点组，2019-2020年确定了13个时间-地点组; 23个组中有19个组包含≤4例患者。2017-2018年，10组中有6组有≥2例患者有序列数据，包括≥1例HAII病例。13个小组中有两个在2019-2020年达到了这一标准。2017-2018年的两个时间-地点组各包含3例基因相关病例。我们的研究结果表明，HAIIs来自医院来源的爆发传播以及独特的社区引入的单一感染。
Hospital-acquired influenza virus infection (HAII) can cause severe morbidity and mortality. Identifying potential transmission routes can inform prevention strategies. We identified all hospitalized patients testing positive for influenza A virus at a large, tertiary care hospital during the 2017–2018 and 2019–2020 influenza seasons. Hospital admission dates, locations of inpatient service, and clinical influenza testing information were retrieved from the electronic medical record. Time-location groups of epidemiologically linked influenza patients were defined and contained ≥1 presumed HAII case (first positive ≥48 hours after admission). Genetic relatedness within time-location groups was assessed by whole genome sequencing. During the 2017–2018 season, 230 patients tested positive for influenza A(H3N2) or unsubtyped influenza A including 26 HAIIs. There were 159 influenza A(H1N1)pdm09 or unsubtyped influenza A–positive patients identified during the 2019–2020 season including 33 HAIIs. Consensus sequences were obtained for 177 (77%) and 57 (36%) of influenza A cases in 2017–2018 and 2019–2020, respectively. Among all influenza A cases, there were 10 time-location groups identified in 2017–2018 and 13 in 2019–2020; 19 of 23 groups included ≤4 patients. In 2017–2018, 6 of 10 groups had ≥2 patients with sequence data, including ≥1 HAII case. Two of 13 groups met this criteria in 2019–2020. Two time-location groups from 2017–2018 each contained 3 genetically linked cases. Our results suggest that HAIIs arise from outbreak transmission from nosocomial sources as well as single infections from unique community introductions.
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影响因子：
6.9
作者：
Eibach, D.;Casalegno, J. -S.;Lina, B.
通讯作者：
Lina, B.
影响因子：
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作者：
MacFadden, Derek R.;McGeer, Allison;Hanage, William P.
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Hanage, William P.
影响因子：
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作者：
Petrie, Joshua G.;Talbot, Thomas R.
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Talbot, Thomas R.
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Filipenko, Maxim
影响因子：
3.7
作者：
Godoy, P.;Torner, N.;Force, L. L.
通讯作者：
Force, L. L.