The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties.
The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties.
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DOI：
10.1007/s10719-012-9464-4
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发表时间：
2013-10
影响因子：
3
通讯作者：
Roque-Barreira, Maria Cristina
中科院分区：
文献类型：
--
作者：
Souza, Maria A.;Carvalho, Fernanda C.;Ruas, Luciana P.;Ricci-Azevedo, Rafael;Roque-Barreira, Maria Cristina
糖生物学和免疫学领域的进展为碳水化合物-蛋白质相互作用在免疫系统中的作用提供了许多见解。我们的目的是提出一个全面的审查的影响，一些植物凝集素发挥免疫调节剂，表明它们能够积极修改某些病理条件下，如癌症和感染的免疫反应。本文综述了4个方面的内容：（1）植物凝集素的免疫调节作用及其作用机制;（2）木菠萝籽凝集素ArtinM的一般特性;（3）ArtinM对天然免疫细胞的激活作用及其诱导Th 1免疫的作用;（4）植物凝集素ArtinM对天然免疫细胞的免疫调节作用;（4）ArtinM给药在感染胞内病原体如硕大利什曼原虫（Leishmania）、亚马逊利什曼原虫（Leishmania）amazonensis和巴西副球孢子虫（Paracoccidioides brasiliensis）中赋予的抗性。我们相信，这一审查将是一个宝贵的资源，更多的研究在这个相对被忽视的研究领域，这有可能揭示新的预防和治疗策略的碳水化合物的目标。
Advances in the glycobiology and immunology fields have provided many insights into the role of carbohydrate-protein interactions in the immune system. We aim to present a comprehensive review of the effects that some plant lectins exert as immunomodulatory agents, showing that they are able to positively modify the immune response to certain pathological conditions, such as cancer and infections. The present review comprises four main themes: (1) an overview of plant lectins that exert immunomodulatory effects and the mechanisms accounting for these activities; (2) general characteristics of the immunomodulatory lectin ArtinM from the seeds of Artocarpus heterophyllus; (3) activation of innate immunity cells by ArtinM and consequent induction of Th1 immunity; (4) resistance conferred by ArtinM administration in infections with intracellular pathogens, such as Leishmania (Leishmania) major, Leishmania (Leishmania) amazonensis, and Paracoccidioides brasiliensis. We believe that this review will be a valuable resource for more studies in this relatively neglected area of research, which has the potential to reveal carbohydrate targets for novel prophylactic and therapeutic strategies.
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影响因子：
2.9
作者：
BAUSCH, JN;PORETZ, RD
通讯作者：
PORETZ, RD
影响因子：
6
作者：
Bernardes, Emerson Soares;Silva, Neide M.;Roque-Barreira, Maria Cristina
通讯作者：
Roque-Barreira, Maria Cristina
影响因子：
4.8
作者：
Correia, JD;Ulevitch, RJ
通讯作者：
Ulevitch, RJ
DOI：
10.1590/s0036-46651986000500004
发表时间：
1986-09-01
影响因子：
1.9
作者：
DEMAGALHAES, AV;MORAES, MAP;MARSDEN, PD
通讯作者：
MARSDEN, PD
影响因子：
3.9
作者：
Agrawal, S.;Kandimalla, E. R.
通讯作者：
Kandimalla, E. R.