Genetics of methamphetamine use disorder: A systematic review and meta-analyses of gene association studies.
Genetics of methamphetamine use disorder: A systematic review and meta-analyses of gene association studies.
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甲基苯丙胺使用障碍的遗传学：基因关联研究的系统评价和荟萃分析。
DOI：
10.1016/j.neubiorev.2020.11.001
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发表时间：
2021-01
影响因子：
8.2
通讯作者：
Kim JH
中科院分区：
文献类型：
--
作者：
Guerin AA;Nestler EJ;Berk M;Lawrence AJ;Rossell SL;Kim JH
甲基苯丙胺使用障碍的遗传易感性知之甚少。尚未进行双胞胎或充分把握度的全基因组关联研究（GWAS）。然而，有大量的假设驱动的候选基因关联的研究，这是系统地审查在这里。76项研究被确定，调查了75个不同基因的标记。计算等位基因频率、比值比、95%可信区间和功效.偏倚风险也作为质量指标进行了评估。如果有三项或三项以上研究可用，则对基因标记物进行荟萃分析。来自充分把握度研究的11个标志物与甲基苯丙胺使用障碍显著相关，脂肪酸酰胺水解酶（FAAH）和脑源性神经营养因子（BDNF）代表有希望的靶点。这些研究的局限性包括候选基因选择的理论依据不明确、效力低和偏倚风险高。未来的研究应该包括重复，以实现更多的荟萃分析，强大的GWAS或全外显子组或基因组测序，以及双胞胎和家庭研究，以进一步补充本综述的发现，以揭示对甲基苯丙胺使用障碍的遗传贡献。
Genetic susceptibility to methamphetamine use disorder is poorly understood. No twin or adequately powered genome-wide association studies (GWASs) have been conducted. However, there are a large number of hypothesis-driven candidate gene association studies, which were systematically reviewed herein. Seventy-six studies were identified, investigating markers of 75 different genes. Allele frequencies, odds ratios, 95 % confidence intervals and power were calculated. Risk of bias was also assessed as a quality measure. Meta-analyses were conducted for gene markers if three or more studies were available. Eleven markers from adequately powered studies were significantly associated with methamphetamine use disorder, with Fatty Acid Amide Hydrolase (FAAH) and Brain Derived Neurotrophic Factor (BDNF) representing promising targets. Limitations of these studies include unclear rationale for candidate gene selection, low power and high risk of bias. Future research should include replications to enable more meta-analyses, well-powered GWASs or whole exome or genome sequencing, as well as twin and family studies to further complement the findings of this review to uncover genetic contributions toward methamphetamine use disorder.
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影响因子：
64.8
作者：
Cheng, MY;Bullock, CM;Zhou, QY
通讯作者：
Zhou, QY
DOI：
10.1111/j.1530-0277.2006.00215.x
发表时间：
2006-10-01
影响因子：
3.2
作者：
Aoyama, Nagisa;Takahashi, Nagahide;Ozaki, Norio
通讯作者：
Ozaki, Norio
影响因子：
9.8
作者：
Boutin P;Dina C;Vasseur F;Dubois S;Corset L;Séron K;Bekris L;Cabellon J;Neve B;Vasseur-Delannoy V;Chikri M;Charles MA;Clement K;Lernmark A;Froguel P
通讯作者：
Froguel P
影响因子：
10.6
作者：
Caprioli D;Venniro M;Zeric T;Li X;Adhikary S;Madangopal R;Marchant NJ;Lucantonio F;Schoenbaum G;Bossert JM;Shaham Y
通讯作者：
Shaham Y
影响因子：
2.5
作者：
Chanasong, Rachanee;Thanoi, Samur;Nudmamud-Thanoi, Sutisa
通讯作者：
Nudmamud-Thanoi, Sutisa