Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking.
Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking.
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DOI：
10.1016/j.jalz.2011.10.006
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Alzheimer Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Durazzo TC;Insel PS;Weiner MW;Alzheimer Disease Neuroimaging Initiative
关于吸烟对老年人大脑形态学变化的影响知之甚少。本研究调查了吸烟史对健康、认知功能完整的老年人2年内局部脑体积变化的影响。我们预测，与从不吸烟者相比，有吸烟史的人在阿尔茨海默病（AD）早期表现出形态异常的区域中，以及扩展的大脑奖励系统（BRS）中，在2年内表现出更大的萎缩率，这与物质使用障碍的发展和维持有关。参与者为健康、认知正常的老年对照组（75.9±4.8岁），有任何吸烟史（n = 68）和无吸烟史（n = 118）。数据来自2005-2010年的阿尔茨海默病神经成像计划。参与者在2年内完成了4次磁共振扫描。采用1.5特斯拉的高分辨率3D T1加权序列的标准化方案用于结构成像和局部脑体积分析。吸烟者表现出显着更大的比率萎缩超过2年比非吸烟者在多个大脑区域与早期阶段的AD以及在BRS。各组在整体皮质萎缩率方面无差异。在这个健康的老年人队列中，吸烟史与多个脑区域的结构完整性降低相关，这表现为在受早期AD以及慢性物质滥用特别影响的区域中，2年内萎缩率更高。
Little is known about the effects of cigarette smoking on brain morphological changes in the elderly. This study investigated the effects of a history of cigarette smoking on changes in regional brain volumes over 2-years in healthy, cognitively-intact elderly individuals. We predicted individuals with a history of cigarette smoking, compared to never smokers, demonstrate greater rate of atrophy over 2-years in regions that manifest morphological abnormalities in the early stages of Alzheimer Disease (AD), as well as the extended brain reward system (BRS), which is implicated in the development and maintenance of substance use disorders. Participants were healthy, cognitively normal elderly controls (75.9±4.8 years of age) with any lifetime history of cigarette smoking (n = 68) and no history of smoking (n = 118). Data was obtained via the Alzheimer Disease Neuroimaging Initiative from 2005–2010. Participants completed four magnetic resonance scans over 2-years. A standardized protocol employing high resolution 3D T1-weighted sequences at 1.5 Tesla was used for structural imaging and regional brain volumetric analyses. Smokers demonstrated significantly greater rate atrophy over 2-years than non-smokers in multiple brain regions associated with the early stages of AD as well as in the BRS. Groups were not different on rate of global cortical atrophy. A history of cigarette smoking in this healthy elderly cohort was associated with decreased structural integrity of multiple brain regions, which was manifest as a greater rate of atrophy over 2-years in regions specifically affected by incipient AD as well as chronic substance abuse.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
4.2
作者：
Cardenas, V. A.;Chao, L. L.;Studholme, C.;Yaffe, K.;Miller, B. L.;Madison, C.;Buckley, S. T.;Mungas, D.;Schuff, N.;Weiner, M. W.
通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
Staedtgen, Mario
影响因子：
17.7
作者：
Kalivas, PW;Volkow, ND
通讯作者：
Volkow, ND
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y