Brain atrophy associated with baseline and longitudinal measures of cognition.
Brain atrophy associated with baseline and longitudinal measures of cognition.
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DOI：
10.1016/j.neurobiolaging.2009.04.011
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发表时间：
2011-04
影响因子：
4.2
通讯作者：
Weiner, M. W.
中科院分区：
文献类型：
--
作者：
Cardenas, V. A.;Chao, L. L.;Studholme, C.;Yaffe, K.;Miller, B. L.;Madison, C.;Buckley, S. T.;Mungas, D.;Schuff, N.;Weiner, M. W.
总体目标是确定与非痴呆老年人认知障碍和未来认知能力下降相关的脑萎缩模式。在基线和1年随访时，对71名参与者进行了结构MRI和神经心理学测试。基于变形的形态测量学被用来检查区域基线脑组织体积与延迟言语记忆、语义记忆和执行功能的基线和纵向测量之间的关系。基线时右侧海马和内嗅皮层（ERC）体积较小与基线时延迟言语记忆表现较差相关，而左侧ERC体积较小与纵向下降较大相关。基线时较小的左上级颞叶皮层与基线时较差的语义记忆相关，而较小的左颞叶白色和灰质体积与较大的语义记忆下降相关。CSF增加和额叶体积减小与基线时执行功能受损和纵向执行功能下降更大相关。这些研究结果表明，在非痴呆老年人中，前额叶和颞叶区域的基线体积可能是由于衰老、病理或两者兼而有之而导致的持续认知下降的基础。
The overall goal was to identify patterns of brain atrophy associated with cognitive impairment and future cognitive decline in non-demented elders. Seventy-one participants were studied with structural MRI and neuropsychological testing at baseline and 1 year follow-up. Deformation-based morphometry was used to examine the relationship between regional baseline brain tissue volume with baseline and longitudinal measures of delayed verbal memory, semantic memory, and executive function. Smaller right hippocampal and entorhinal cortex (ERC) volumes at baseline were associated with worse delayed verbal memory performance at baseline while smaller left ERC volume was associated with greater longitudinal decline. Smaller left superior temporal cortex at baseline was associated with worse semantic memory at baseline, while smaller left temporal white and gray matter volumes were associated with greater semantic memory decline. Increased CSF and smaller frontal lobe volumes were associated with impaired executive function at baseline and greater longitudinal executive decline. These findings suggest that baseline volumes of prefrontal and temporal regions may underlie continuing cognitive decline due to aging, pathology, or both in non-demented elderly individuals.
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影响因子：
3.6
作者：
Mungas, D;Reed, BR;González, H
通讯作者：
González, H
DOI：
10.1017/s1355617705051015
发表时间：
2005-11-01
影响因子：
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作者：
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作者：
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作者：
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通讯作者：
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