Stability Analysis of a Renewal Equation for Cell Population Dynamics with Quiescence
Stability Analysis of a Renewal Equation for Cell Population Dynamics with Quiescence
复制标题
静止细胞群动态更新方程的稳定性分析
DOI:
10.1137/130940438
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发表时间:
2014
期刊:
影响因子:
--
通讯作者:
Y. Nakata
中科院分区:
文献类型:
--
作者:
T. Alarcón;Ph. Getto;Y. Nakata
We propose a model to analyze the dynamics of interacting proliferating and quiescent cell populations. The model includes age dependence of cell division, transitions between the two subpopulations, and regulation of the recruitment of quiescent cells. We formulate the model as a pair of renewal equations and apply a rather recent general result to prove that (in)stability of equilibria can be analyzed by locating roots of characteristic equations. We are led to a parameter plane analysis of a characteristic equation, which has not been analyzed in this way so far. We conclude with how quiescence of cells as well as two submodels for cell division may influence the possibility of destabilization via oscillations.
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