Development, plasticity and modulation of visceral afferents.
Development, plasticity and modulation of visceral afferents.
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DOI：
10.1016/j.brainresrev.2008.12.004
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发表时间：
2009-04
影响因子：
--
通讯作者：
Vergnolle N
中科院分区：
文献类型：
--
作者：
Christianson JA;Bielefeldt K;Altier C;Cenac N;Davis BM;Gebhart GF;High KW;Kollarik M;Randich A;Undem B;Vergnolle N
在美国，内脏疼痛是就诊的最常见原因。与躯体疼痛一样，几乎所有内脏痛感都始于支配内脏和/或与这些结构相关的血管的初级感觉神经元的激活。内脏传入在组织内稳态中也起着核心作用。最近的研究表明，除了监测内脏的状态外，它们还通过释放小分子(例如像CGRP这样的肽)来执行传出功能，这些小分子可以推动炎症，从而促进内脏病理的发展(例如糖尿病Razavi，R.，Chan，Y.，Afiyan，F.N.，Liu，X.J.，wan，X.，Yantha，J.，Tsui，H.，Tang，L.，Tsai，S.，Santamaria，P.，Driver，J.P.，Serreze，D.，Salter，M.W.，Dosch，H.M.，2006年。TRPV1+感觉神经元控制自身免疫性糖尿病的β细胞应激和胰岛炎症(细胞127 1123-1135)。内脏传入在解剖、神经化学和功能方面是不同的。它们也是高度可塑性的，因为它们的蜂窝环境不断地影响它们的响应特性。这种可塑性使它们容易受到长期变化的影响，这些变化可能会显著促进持续性疼痛状态的发展，如与肠易激综合征、胰腺炎和内脏癌症相关的疼痛状态。这篇综述考察了对内脏传入解剖和神经化学的最新见解，以及新生儿侮辱如何影响成人这些神经元的功能。治疗内脏疼痛的新方法，重点是初级传入，也将被讨论。
Visceral pain is the most common reason for doctor visits in the US. Like somatic pain, virtually all visceral pain sensations begin with the activation of primary sensory neurons innervating the viscera and/or the blood vessels associated with these structures. Visceral afferents also play a central role in tissue homeostasis. Recent studies show that in addition to monitoring the state of the viscera, they perform efferent functions through the release of small molecules (e.g. peptides like CGRP) that can drive inflammation, thereby contributing to the development of visceral pathologies (e.g. diabetes Razavi, R., Chan, Y., Afifiyan, F.N., Liu, X.J., Wan, X., Yantha, J., Tsui, H., Tang, L., Tsai, S., Santamaria, P., Driver, J.P., Serreze, D., Salter, M.W., Dosch, H.M., 2006. TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes, Cell 127 1123–1135). Visceral afferents are heterogeneous with respect to their anatomy, neurochemistry and function. They are also highly plastic in that their cellular environment continuously influences their response properties. This plasticity makes them susceptible to long-term changes that may contribute significantly to the development of persistent pain states such as those associated with irritable bowel syndrome, pancreatitis, and visceral cancers. This review examines recent insights into visceral afferent anatomy and neurochemistry and how neonatal insults can affect the function of these neurons in the adult. New approaches to the treatment of visceral pain, which focus on primary afferents, will also be discussed.
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DOI：
10.1523/jneurosci.5369-07.2008
发表时间：
2008-03-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andersson DA;Gentry C;Moss S;Bevan S
通讯作者：
Bevan S
影响因子：
29.4
作者：
Brierley, SM;Jones, RCW;Blackshaw, LA
通讯作者：
Blackshaw, LA
影响因子：
2.1
作者：
Andersson, KE
通讯作者：
Andersson, KE
影响因子：
7.4
作者：
Bartocci, M;Bergqvist, LL;Anand, KJS
通讯作者：
Anand, KJS
影响因子：
29.4
作者：
Carter, R.;Jones, W., III;Gebhart, G. F.
通讯作者：
Gebhart, G. F.