Entorhinal cortical Island cells regulate temporal association learning with long trace period.
Entorhinal cortical Island cells regulate temporal association learning with long trace period.
复制标题
内嗅皮层岛细胞调节具有长踪迹周期的颞叶联想学习。
DOI：
10.1101/lm.052589.120
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Kitamura T
中科院分区：
文献类型：
--
作者：
Yokose J;Marks WD;Yamamoto N;Ogawa SK;Kitamura T
时态关联学习(TAL)允许在一段时间内将不同的、非同步的事件联系起来。这一功能是由内嗅皮层-海马网络中的神经相互作用所驱动的，特别是内侧内嗅皮层(MECIII)第三层锥体细胞向海马CA1区的神经传入是TAL的关键。成功的TAL取决于事件刺激的强度和事件之间的时间间隔的持续时间。已有研究表明，当事件刺激强度较弱时，MEC第二层锥体细胞对CA1区抑制神经元的神经传入控制TAL，但尚不清楚岛细胞是否也具有较长的踪迹周期。为了了解岛细胞在调节TAL可学习踪迹期持续时间中的作用，我们使用了具有60秒长踪迹期的巴甫洛夫痕迹恐惧条件反射(L-TFC)，结合光发生和化学发生神经活动操作以及针对细胞类型的神经消融。我们发现，消融MECII中的岛细胞部分地提高了L-TFC的性能。对胰岛细胞的化学遗传操作会导致胰岛细胞活性的不同有效性，并导致电路失衡，从而扰乱L-TFC。然而，在时间关联期，光遗传终末抑制了岛状细胞对背侧海马CA1的输入，使得在TFC中可以学习到长的踪迹间隔。这些结果表明，岛状细胞在调节TAL中相关事件之间可跨越的持续时间方面起着关键作用。
Temporal association learning (TAL) allows for the linkage of distinct, nonsynchronous events across a period of time. This function is driven by neural interactions in the entorhinal cortical–hippocampal network, especially the neural input from the pyramidal cells in layer III of medial entorhinal cortex (MECIII) to hippocampal CA1 is crucial for TAL. Successful TAL depends on the strength of event stimuli and the duration of the temporal gap between events. Whereas it has been demonstrated that the neural input from pyramidal cells in layer II of MEC, referred to as Island cells, to inhibitory neurons in dorsal hippocampal CA1 controls TAL when the strength of event stimuli is weak, it remains unknown whether Island cells regulate TAL with long trace periods as well. To understand the role of Island cells in regulating the duration of the learnable trace period in TAL, we used Pavlovian trace fear conditioning (TFC) with a 60-sec long trace period (long trace fear conditioning [L-TFC]) coupled with optogenetic and chemogenetic neural activity manipulations as well as cell type-specific neural ablation. We found that ablation of Island cells in MECII partially increases L-TFC performance. Chemogenetic manipulation of Island cells causes differential effectiveness in Island cell activity and leads to a circuit imbalance that disrupts L-TFC. However, optogenetic terminal inhibition of Island cell input to dorsal hippocampal CA1 during the temporal association period allows for long trace intervals to be learned in TFC. These results demonstrate that Island cells have a critical role in regulating the duration of time bridgeable between associated events in TAL.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
3.5
作者：
Johnson, Sarah A.;Zequeira, Sabrina;Turner, Sean M.;Maurer, Andrew P.;Bizon, Jennifer L.;Burke, Sara N.
通讯作者：
Burke, Sara N.
影响因子：
2
作者：
Gilmartin, Marieke R.;Helmstetter, Fred J.
通讯作者：
Helmstetter, Fred J.
影响因子：
3.4
作者：
Grosser, Sabine;Barreda, Federico J.;Vida, Imre
通讯作者：
Vida, Imre
影响因子：
3
作者：
Guimarãis M;Gregório A;Cruz A;Guyon N;Moita MA
通讯作者：
Moita MA