Rodent mnemonic similarity task performance requires the prefrontal cortex.
Rodent mnemonic similarity task performance requires the prefrontal cortex.
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DOI：
10.1002/hipo.23316
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发表时间：
2021-07
期刊：
影响因子：
3.5
通讯作者：
Burke, Sara N.
中科院分区：
文献类型：
--
作者：
Johnson, Sarah A.;Zequeira, Sabrina;Turner, Sean M.;Maurer, Andrew P.;Bizon, Jennifer L.;Burke, Sara N.
记忆相似性任务的表现，其中一个已知的目标刺激必须区分类似的诱饵，是由海马和嗅周皮层。这方面的障碍是众所周知的，随着年龄的增长而显现。有趣的是，当诱饵是新的时，干扰海马活动会导致记忆辨别障碍，而当它们是熟悉的时则不会。这一观察结果表明，随着刺激的学习，其他大脑结构也支持辨别能力。前额叶皮层（PFC）对于远程事件的检索和执行功能（如工作记忆）至关重要，并且在衰老时也特别容易出现功能障碍。重要的是，内侧PFC与嗅周皮质相连，该区域的神经元放电协调外侧内嗅和嗅周皮质之间的通信，从而可能调节海马活动。内侧前额叶皮层的这种解剖结构和功能表明，它有助于记忆辨别;然而，这一概念尚未得到实证检验。在目前的研究中，大鼠进行了训练的乐高物体为基础的记忆相似性任务适合啮齿动物，并通过手术植入引导插管，目标前边缘和边缘下区的内侧PFC。记忆辨别测试之前，大鼠接受PFC输注的GABAA激动剂蝇蕈醇。内侧PFC和邻近皮质区域的神经元活性依赖性即刻早期基因Arc的表达分析证实蝇蕈醇输注导致边缘下和边缘前皮质的神经元失活。此外，当诱饵与目标共享50-90%的特征重叠时，在PFC中输注蝇蕈醇相对于溶剂对照在所有测试块中损害记忆辨别性能。因此，相反，海马输注，PFC失活受损的目标诱饵歧视的新奇或熟悉的诱惑。这些结果表明，PFC在记忆相似性任务中起着关键作用，但PFC参与的时间过程是分离的海马。
Mnemonic similarity task performance, in which a known target stimulus must be distinguished from similar lures, is supported by the hippocampus and perirhinal cortex. Impairments on this task are known to manifest with advancing age. Interestingly, disrupting hippocampal activity leads to mnemonic discrimination impairments when lures are novel, but not when they are familiar. This observation suggests that other brain structures support discrimination abilities as stimuli are learned. The prefrontal cortex (PFC) is critical for retrieval of remote events and executive functions, such as working memory, and is also particularly vulnerable to dysfunction in aging. Importantly, the medial PFC is reciprocally connected to the perirhinal cortex and neuron firing in this region coordinates communication between lateral entorhinal and perirhinal cortices to presumably modulate hippocampal activity. This anatomical organization and function of the medial PFC suggests that it contributes to mnemonic discrimination; however, this notion has not been empirically tested. In the current study, rats were trained on a LEGO object-based mnemonic similarity task adapted for rodents, and surgically implanted with guide cannulae targeting prelimbic and infralimbic regions of the medial PFC. Prior to mnemonic discrimination tests, rats received PFC infusions of the GABAA agonist muscimol. Analyses of expression of the neuronal activity-dependent immediate-early gene Arc in medial PFC and adjacent cortical regions confirmed muscimol infusions led to neuronal inactivation in the infralimbic and prelimbic cortices. Moreover, muscimol infusions in PFC impaired mnemonic discrimination performance relative to the vehicle control across all testing blocks when lures shared 50–90% feature overlap with the target. Thus, in contrast hippocampal infusions, PFC inactivation impaired target-lure discrimination regardless of the novelty or familiarity of the lures. These findings indicate the PFC plays a critical role in mnemonic similarity task performance, but the time course of PFC involvement is dissociable from that of the hippocampus.
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影响因子：
2.4
作者：
Lee I;Byeon JS
通讯作者：
Byeon JS
影响因子：
3.7
作者：
Bennett, Ilana J.;Huffman, Derek J.;Stark, Craig E. L.
通讯作者：
Stark, Craig E. L.
影响因子：
15.9
作者：
Burke SN;Gaynor LS;Barnes CA;Bauer RM;Bizon JL;Roberson ED;Ryan L
通讯作者：
Ryan L
影响因子：
5.3
作者：
Bartko, Susan J.;Winters, Boyer D.;Bussey, Timothy J.
通讯作者：
Bussey, Timothy J.
DOI：
10.1037/h0081022
发表时间：
1980-01-01
期刊：
CANADIAN JOURNAL OF PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE
影响因子：
--
作者：
BARNES, CA;NADEL, L;HONIG, WK
通讯作者：
HONIG, WK