Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination.
Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination.
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DOI：
10.3389/fcimb.2012.00168
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发表时间：
2012
影响因子：
5.7
通讯作者：
Ishii KJ
中科院分区：
文献类型：
--
作者：
Jounai N;Kobiyama K;Takeshita F;Ishii KJ
所有哺乳动物细胞都配备了大量的传感器，以保护免受各种入侵者的侵害，而这些入侵者又配备了含有病原体相关分子模式（PAMP）的分子。一旦这些传感器识别含有PAMP的非自身抗原，就会诱导包括炎症在内的各种生理反应以消除病原体。然而，宿主有时遭受慢性感染或持续损伤，导致产生含有损伤相关分子模式（DAMP）的自身分子。DAMP也负责消除病原体，但是已经报道了通过针对PAMP的传感器对DAMP的混杂识别。DAMPs的积累导致大量炎症和DAMPs的持续产生;也就是说，恶性循环导致自身免疫性疾病的发展。从疫苗学的角度来看，PAMP和DAMP的准确识别对于疫苗免疫原性非常重要，因为疫苗佐剂由几种PAMP和/或DAMP组成，它们也与疫苗接种后的严重不良事件相关。在这里，我们回顾了PAMPs和DAMPs在感染病原体或炎症时的作用，以及负责识别它们的传感器，以及它们与自身免疫性疾病的发展或疫苗的免疫原性的关系。
All mammalian cells are equipped with large numbers of sensors for protection from various sorts of invaders, who, in turn, are equipped with molecules containing pathogen-associated molecular patterns (PAMPs). Once these sensors recognize non-self antigens containing PAMPs, various physiological responses including inflammation are induced to eliminate the pathogens. However, the host sometimes suffers from chronic infection or continuous injuries, resulting in production of self-molecules containing damage-associated molecular patterns (DAMPs). DAMPs are also responsible for the elimination of pathogens, but promiscuous recognition of DAMPs through sensors against PAMPs has been reported. Accumulation of DAMPs leads to massive inflammation and continuous production of DAMPs; that is, a vicious circle leading to the development of autoimmune disease. From a vaccinological point of view, the accurate recognition of both PAMPs and DAMPs is important for vaccine immunogenicity, because vaccine adjuvants are composed of several PAMPs and/or DAMPs, which are also associated with severe adverse events after vaccination. Here, we review as the roles of PAMPs and DAMPs upon infection with pathogens or inflammation, and the sensors responsible for recognizing them, as well as their relationship with the development of autoimmune disease or the immunogenicity of vaccines.
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影响因子：
30.5
作者：
Buerckstuemmer, Tilmann;Baumann, Christoph;Superti-Furga, Giulio
通讯作者：
Superti-Furga, Giulio
影响因子：
4.4
作者：
Gorden, Keith K. B.;Qiu, Xiaohong X.;Alkan, Sefik S.
通讯作者：
Alkan, Sefik S.
影响因子：
4.8
作者：
Bamming, Darja;Horvath, Curt M.
通讯作者：
Horvath, Curt M.
影响因子：
27.4
作者：
CHAMBERS, RE;MACFARLANE, DG;DIEPPE, PA
通讯作者：
DIEPPE, PA
尖端：TLR2是急性阶段血清淀粉样蛋白A的功能受体。
DOI：
10.4049/jimmunol.181.1.22
发表时间：
2008-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cheng N;He R;Tian J;Ye PP;Ye RD
通讯作者：
Ye RD